Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)
1_MNNHV 6_ SSKPS 11_ TMKLK 16_ HTINP 21_ ILLYF 26_ IHFLI 31_ SLYTI 36_ LTYIP 41_ FYFFS 46_ ESRQE 51_ KSNRI 56_ KAKPV 61_ NSKPD 66_ SAYRS 71_ VNSLD 76_ GLASV 81_ LYPGC 86_ DTLDK 91_ VFTYA 96_ KNKFK 101_ NKRLL 106_ GTREV 111_ LNEED 116_ EVQPN 121_ GKIFK 126_ KVILG 131_ QYNWL 136_ SYEDV 141_ FVRAF 146_ NFGNG 151_ LQMLG 156_ QKPKT 161_ NIAIF 166_ CETRA 171_ EWMIA 176_ AQACF 181_ MYNFQ 186_ LVTLY 191_ ATLGG 196_ PAIVH 201_ ALNET 206_ EVTNI 211_ ITSKE 216_ LLQTK 221_ LKDIV 226_ SLVPR 231_ LRHII 236_ TVDGK 241_ PPTWS 246_ EFPKG 251_ IIVHT 256_ MAAVE 261_ ALGAK 266_ ASMEN 271_ QPHSK 276_ PLPSD 281_ IAVIM 286_ YTSGS 291_ TGLPK 296_ GVMIS 301_ HSNII 306_ AGITG 311_ MAERI 316_ PELGE 321_ EDVYI 326_ GYLPL 331_ AHVLE 336_ LSAEL 341_ VCLSH 346_ GCRIG 351_ YSSPQ 356_ TLADQ 361_ SSKIK 366_ KGSKG 371_ DTSML 376_ KPTLM 381_ AAVPE 386_ IMDRI 391_ YKNVM 396_ NKVSE 401_ MSSFQ 406_ RNLFI 411_ LAYNY 416_ KMEQI 421_ SKGRN 426_ TPLCD 431_ SFVFR 436_ KVRSL 441_ LGGNI 446_ RLLLC 451_ GGAPL 456_ SATTQ 461_ RFMNI 466_ CFCCP 471_ VGQGY 476_ GLTES 481_ AGAGT 486_ ISEVW 491_ DYNTG 496_ RVGAP 501_ LVCCE 506_ IKLKN 511_ WEEGG 516_ YFNTD 521_ KPHPR 526_ GEILI 531_ GGQSV 536_ TMGYY 541_ KNEAK 546_ TKADF 551_ FEDEN 556_ GQRWL 561_ CTGDI 566_ GEFEP 571_ DGCLK 576_ IIDRK 581_ KDLVK 586_ LQAGE 591_ YVSLG 596_ KVEAA 601_ LKNLP 606_ LVDNI 611_ CAYAN 616_ SYHSY 621_ VIGFV 626_ VPNQK 631_ ELTEL 636_ ARKKG 641_ LKGTW 646_ EELCN 651_ SCEME 656_ NEVLK 661_ VLSEA 666_ AISAS 671_ LEKFE 676_ IPVKI 681_ RLSPE 686_ PWTPE 691_ TGLVT 696_ DAFKL 701_ KRKEL 706_ KTHYQ 711_ADIER
1: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity)