YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1)
1_MFKRM 6_ AEFGP 11_ DSGGR 16_ VKGVT 21_ IVKPI 26_ VYGNV 31_ ARYFG 36_ KKREE 41_ DGHTH 46_ QWTVY 51_ VKPYR 56_ NEDMS 61_ AYVKK 66_ IQFKL 71_ HESYG 76_ NPLRV 81_ VTKPP 86_ YEITE 91_ TGWGE 96_ FEIII 101_ KIFFI 106_ DPNER 111_ PVTLY 116_ HLLKL 121_ FQSDT 126_ NAMLG 131_ KKTVV 136_ SEFYD 141_ EMIFQ 146_ DPTAM 151_ MQQLL 156_ TTSRQ 161_ LTLGA 166_ YKHET 171_ EFAEL 176_ EVKTR 181_ EKLEA 186_ AKKKT 191_ SFEIA 196_ ELKER 201_ LKASR 206_ ETINC 211_ LKNEI 216_ RKLEE 221_DDQAK
1: Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:29900004, PubMed:30071723). Also able to recognize and bind crotonylated histone H3 (PubMed:30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed:29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed:29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity)