CCR4-NOT transcription complex subunit 4 (EC 2.3.2.27) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) (RING-type E3 ubiquitin transferase CNOT4)
1_MSRSP 6_ DAKED 11_ PVECP 16_ LCMEP 21_ LEIDD 26_ INFFP 31_ CTCGY 36_ QICRF 41_ CWHRI 46_ RTDEN 51_ GLCPA 56_ CRKPY 61_ PEDPA 66_ VYKPL 71_ SQEEL 76_ QRIKN 81_ EKKQK 86_ QNERK 91_ QKISE 96_ NRKHL 101_ ASVRV 106_ VQKNL 111_ VFVVG 116_ LSQRL 121_ ADPEV 126_ LKRPE 131_ YFGKF 136_ GKIHK 141_ VVINN 146_ STSYA 151_ GSQGP 156_ SASAY 161_ VTYIR 166_ SEDAL 171_ RAIQC 176_ VNNVV 181_ VDGRT 186_ LKASL 191_ GTTKY 196_ CSYFL 201_ KNMQC 206_ PKPDC 211_ MYLHE 216_ LGDEA 221_ ASFTK 226_ EEMQA 231_ GKHQE 236_ YEQKL 241_ LQELY 246_ KLNPN 251_ FLQLS 256_ TGSVD 261_ KNKNK 266_ VTPLQ 271_ RYDTP 276_ IDKPS 281_ DSLSI 286_ GNGDN 291_ SQQIS 296_ NSDTP 301_ SPPPG 306_ LSKSN 311_ PVIPI 316_ SSSNH 321_ SARSP 326_ FEGAV 331_ TESQS 336_ LFSDN 341_ FRHPN 346_ PIPSG 351_ LPPFP 356_ SSPQT 361_ SSDWP 366_ TAPEP 371_ QSLFT 376_ SETIP 381_ VSSST 386_ DWQAA 391_ FGFGS 396_ SKQPE 401_ DDLGF 406_ DPFDV 411_ TRKAL 416_ ADLIE 421_ KELSV 426_ QDQPS 431_ LSPTS 436_ LQNSS 441_ SHTTT 446_ AKGPG 451_ SGFLH 456_ PAAAT 461_ NANSL 466_ NSTFS 471_ VLPQR 476_ FPQFQ 481_ QHRAV 486_ YNSFS 491_ FPGQA 496_ ARYPW 501_ MAFPR 506_ NSIMH 511_ LNHTA 516_ NPTSN 521_ SNFLD 526_ LNLPP 531_ QHNTG 536_ LGGIP 541_ VAGEE 546_ EVKVS 551_ TMPLS 556_ TSSHS 561_ LQQGQ 566_QPTSL
1: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391)