STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase)
1_MSDHG 6_ DVSLP 11_ PEDRV 16_ RALSQ 21_ LGSAV 26_ EVNED 31_ IPPRR 36_ YFRSG 41_ VEIIR 46_ MASIY 51_ SEEGN 56_ IEHAF 61_ ILYNK 66_ YITLF 71_ IEKLP 76_ KHRDY 81_ KSAVI 86_ PEKKD 91_ TVKKL 96_ KEIAF 101_ PKAEE 106_ LKAEL 111_ LKRYT 116_ KEYTE 121_ YNEEK 126_ KKEAE 131_ ELARN 136_ MAIQQ 141_ ELEKE 146_ KQRVA 151_ QQKQQ 156_ QLEQE 161_ QFHAF 166_ EEMIR 171_ NQELE 176_ KERLK 181_ IVQEF 186_ GKVDP 191_ GLGGP 196_ LVPDL 201_ EKPSL 206_ DVFPT 211_ LTVSS 216_ IQPSD 221_ CHTTV 226_ RPAKP 231_ PVVDR 236_ SLKPG 241_ ALSNS 246_ ESIPT 251_ IDGLR 256_ HVVVP 261_ GRLCP 266_ QFLQL 271_ ASANT 276_ ARGVE 281_ TCGIL 286_ CGKLM 291_ RNEFT 296_ ITHVL 301_ IPKQS 306_ AGSDY 311_ CNTEN 316_ EEELF 321_ LIQDQ 326_ QGLIT 331_ LGWIH 336_ THPTQ 341_ TAFLS 346_ SVDLH 351_ THCSY 356_ QMMLP 361_ ESVAI 366_ VCSPK 371_ FQETG 376_ FFKLT 381_ DHGLE 386_ EISSC 391_ RQKGF 396_ HPHSK 401_ DPPLF 406_ CSCSH 411_ VTVVD 416_RAVTI
1: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699)