Follistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein)
1_MRPGA 6_ PGPLW 11_ PLPWG 16_ ALAWA 21_ VGFVS 26_ SMGSG 31_ NPAPG 36_ GVCWL 41_ QQGQE 46_ ATCSL 51_ VLQTD 56_ VTRAE 61_ CCASG 66_ NIDTA 71_ WSNLT 76_ HPGNK 81_ INLLG 86_ FLGLV 91_ HCLPC 96_ KDSCD 101_ GVECG 106_ PGKAC 111_ RMLGG 116_ RPRCE 121_ CAPDC 126_ SGLPA 131_ RLQVC 136_ GSDGA 141_ TYRDE 146_ CELRA 151_ ARCRG 156_ HPDLS 161_ VMYRG 166_ RCRKS 171_ CEHVV 176_ CPRPQ 181_ SCVVD 186_ QTGSA 191_ HCVVC 196_ RAAPC 201_ PVPSS 206_ PGQEL 211_ CGNNN 216_ VTYIS 221_ SCHMR 226_ QATCF 231_ LGRSI 236_ GVRHA 241_ GSCAG 246_ TPEEP 251_ PGGES 256_AEEEE
1: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10