Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)]
1_MVLCP 6_ VIGKL 11_ LHKRV 16_ VLASA 21_ SPRRQ 26_ EILSN 31_ AGLRF 36_ EVVPS 41_ KFKEK 46_ LDKAS 51_ FATPY 56_ GYAME 61_ TAKQK 66_ ALEVA 71_ NRLYQ 76_ KDLRA 81_ PDVVI 86_ GADTI 91_ VTVGG 96_ LILEK 101_ PVDKQ 106_ DAYRM 111_ LSRLS 116_ GREHS 121_ VFTGV 126_ AIVHC 131_ SSKDH 136_ QLDTR 141_ VSEFY 146_ EETKV 151_ KFSEL 156_ SEELL 161_ WEYVH 166_ SGEPM 171_ DKAGG 176_ YGIQA 181_ LGGML 186_ VESVH 191_ GDFLN 196_ VVGFP 201_ LNHFC 206_ KQLVK 211_ LYYPP 216_ RPEDL 221_ RRSVK 226_ HDSIP 231_ AADTF 236_ EDLSD 241_ VEGGG 246_ SEPTQ 251_ RDAGS 256_ RDEKA 261_ EAGEA 266_ GQATA 271_ EAECH 276_ RTRET 281_ LPPFP 286_ TRLLE 291_ LIEGF 296_ MLSKG 301_ LLTAC 306_ KLKVF 311_ DLLKD 316_ EAPQK 321_ AADIA 326_ SKVDA 331_ SACGM 336_ ERLLD 341_ ICAAM 346_ GLLEK 351_ TEQGY 356_ SNTET 361_ ANVYL 366_ ASDGE 371_ YSLHG 376_ FIMHN 381_ NDLTW 386_ NLFTY 391_ LEFAI 396_ REGTN 401_ QHHRA 406_ LGKKA 411_ EDLFQ 416_ DAYYQ 421_ SPETR 426_ LRFMR 431_ AMHGM 436_ TKLTA 441_ CQVAT 446_ AFNLS 451_ RFSSA 456_ CDVGG 461_ CTGAL 466_ ARELA 471_ REYPR 476_ MQVTV 481_ FDLPD 486_ IIELA 491_ AHFQP 496_ PGPQA 501_ VQIHF 506_ AAGDF 511_ FRDPL 516_ PSAEL 521_ YVLCR 526_ ILHDW 531_ PDDKV 536_ HKLLS 541_ RVAES 546_ CKPGA 551_ GLLLV 556_ ETLLD 561_ EEKRV 566_ AQRAL 571_ MQSLN 576_ MLVQT 581_ EGKER 586_ SLGEY 591_ QCLLE 596_ LHGFH 601_ QVQVV 606_ HLGGV 611_ LDAIL 616_ATKVA
1: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable)