Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)
1_MTELR 6_ QRVAH 11_ EPVAP 16_ PEDKE 21_ SESEA 26_ KVDGE 31_ TASDS 36_ ESRAE 41_ SAPLP 46_ VSADD 51_ TPEVL 56_ NRALS 61_ NLSSR 66_ WKNWW 71_ VRGIL 76_ TLAMI 81_ AFFFI 86_ IIYLG 91_ PMVLM 96_ IIVMC 101_ VQIKC 106_ FHEII 111_ TIGYN 116_ VYHSY 121_ DLPWF 126_ RTLSW 131_ YFLLC 136_ VNYFF 141_ YGETV 146_ TDYFF 151_ TLVQR 156_ EEPLR 161_ ILSKY 166_ HRFIS 171_ FTLYL 176_ IGFCM 181_ FVLSL 186_ VKKHY 191_ RLQFY 196_ MFGWT 201_ HVTLL 206_ IVVTQ 211_ SHLVI 216_ HNLFE 221_ GMIWF 226_ IVPIS 231_ CVICN 236_ DIMAY 241_ MFGFF 246_ FGRTP 251_ LIKLS 256_ PKKTW 261_ EGFIG 266_ GFFAT 271_ VVFGL 276_ LLSYV 281_ MSGYR 286_ CFVCP 291_ VEYNN 296_ DTNSF 301_ TVDCE 306_ PSDLF 311_ RLQEY 316_ NIPGV 321_ IQSVI 326_ GWKTV 331_ RMYPF 336_ QIHSI 341_ ALSTF 346_ ASLIG 351_ PFGGF 356_ FASGF 361_ KRAFK 366_ IKDFA 371_ NTIPG 376_ HGGIM 381_ DRFDC 386_ QYLMA 391_ TFVNV 396_ YIASF 401_ IRGPN 406_ PSKLI 411_ QQFLT 416_ LRPDQ 421_ QLHIF 426_ NTLRS 431_ HLIDK 436_GMLTS
1: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309)