Eyes absent homolog 4 (EC 3.1.3.48)
1_MEDSQ 6_ DLNEQ 11_ SVKKT 16_ CTESD 21_ VSQSQ 26_ NSRSM 31_ EMQDL 36_ ASPHT 41_ LVGGG 46_ DTPGS 51_ SKLEK 56_ SNLSS 61_ TSVTT 66_ NGTGG 71_ ENMTV 76_ LNTAD 81_ WLLSC 86_ NTPSS 91_ ATMSL 96_ LAVKT 101_ EPLNS 106_ SETTA 111_ TTGDG 116_ ALDTF 121_ TGSVI 126_ TSSGY 131_ SPRSA 136_ HQYSP 141_ QLYPS 146_ KPYPH 151_ ILSTP 156_ AAQTM 161_ SAYAG 166_ QTQYS 171_ GMQQP 176_ AVYTA 181_ YSQTG 186_ QPYSL 191_ PTYDL 196_ GVMLP 201_ AIKTE 206_ SGLSQ 211_ TQSPL 216_ QSGCL 221_ SYSPG 226_ FSTPQ 231_ PGQTP 236_ YSYQM 241_ PGSSF 246_ APSST 251_ IYANN 256_ SVSNS 261_ TNFSG 266_ SQQDY 271_ PSYTA 276_ FGQNQ 281_ YAQYY 286_ SASTY 291_ GAYMT 296_ SNNTA 301_ DGTPS 306_ STSTY 311_ QLQES 316_ LPGLT 321_ NQPGE 326_ FDTMQ 331_ SPSTP 336_ IKDLD 341_ ERTCR 346_ SSGSK 351_ SRGRG 356_ RKNNP 361_ SPPPD 366_ SDLER 371_ VFVWD 376_ LDETI 381_ IVFHS 386_ LLTGS 391_ YAQKY 396_ GKDPP 401_ MAVTL 406_ GLRME 411_ EMIFN 416_ LADTH 421_ LFFND 426_ LEECD 431_ QVHID 436_ DVSSD 441_ DNGQD 446_ LSTYS 451_ FATDG 456_ FHAAA 461_ SSANL 466_ CLPTG 471_ VRGGV 476_ DWMRK 481_ LAFRY 486_ RRVKE 491_ LYNTY 496_ KNNVG 501_ GLLGP 506_ AKRDA 511_ WLQLR 516_ AEIEG 521_ LTDSW 526_ LTNAL 531_ KSLSI 536_ ISTRS 541_ NCINV 546_ LVTTT 551_ QLIPA 556_ LAKVL 561_ LYSLG 566_ GAFPI 571_ ENIYS 576_ ATKIG 581_ KESCF 586_ ERIMQ 591_ RFGRK 596_ VVYVV 601_ IGDGV 606_ EEEQA 611_ AKKHN 616_ MPFWR 621_ ISSHS 626_ DLLAL 631_HQALE
1: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity)