E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
1_MPSES 6_ FCLAA 11_ QARLD 16_ SKWLK 21_ TDIQL 26_ AFTRD 31_ GLCGL 36_ WNEMV 41_ KDGEI 46_ VYTGT 51_ ESTQN 56_ GELPP 61_ RKDDS 66_ VEPSG 71_ TKKED 76_ LNDKE 81_ KKDEE 86_ ETPAP 91_ IYRAK 96_ SILDS 101_ WVWGK 106_ QPDVN 111_ ELKEC 116_ LSVLV 121_ KEQQA 126_ LAVQS 131_ ATTTL 136_ SALRL 141_ KQRLV 146_ ILERY 151_ FIALN 156_ RTVFQ 161_ ENVKV 166_ KWKSS 171_ GISLP 176_ PVDKK 181_ SSRPA 186_ GKGVE 191_ GLARV 196_ GSRAA 201_ LSFAF 206_ AFLRR 211_ AWRSG 216_ EDADL 221_ CSELL 226_ QESLD 231_ ALRAL 236_ PEASL 241_ FDEST 246_ VSSVW 251_ LEVVE 256_ RATRF 261_ LRSVV 266_ TGDVH 271_ GTPAT 276_ KGPGS 281_ IPLQD 286_ QHLAL 291_ AILLE 296_ LAVQR 301_ GTLSQ 306_ MLSAI 311_ LLLLQ 316_ LWDSG 321_ AQETD 326_ NERSA 331_ QGTSA 336_ PLLPL 341_ LQRFQ 346_ SIICR 351_ KDAPH 356_ SEGDM 361_ HLLSG 366_ PLSPN 371_ ESFLR 376_ YLTLP 381_ QDNEL 386_ AIDLR 391_ QTAVV 396_ VMAHL 401_ DRLAT 406_ PCMPP 411_ LCSSP 416_ TSHKG 421_ SLQEV 426_ IGWGL 431_ IGWKY 436_ YANVI 441_ GPIQC 446_ EGLAN 451_ LGVTQ 456_ IACAE 461_ KRFLI 466_ LSRNG 471_ RVYTQ 476_ AYNSD 481_ TLAPQ 486_ LVQGL 491_ ASRNI 496_ VKIAA 501_ HSDGH 506_ HYLAL 511_ AATGE 516_ VYSWG 521_ CGDGG 526_ RLGHG 531_ DTVPL 536_ EEPKV 541_ ISAFS 546_ GKQAG 551_ KHVVH 556_ IACGS 561_ TYSAA 566_ ITAEG 571_ ELYTW 576_ GRGNY 581_ GRLGH 586_ GSSED 591_ EAIPM 596_ LVAGL 601_ KGLKV 606_ IDVAC 611_ GSGDA 616_ QTLAV 621_ TENGQ 626_ VWSWG 631_ DGDYG 636_ KLGRG 641_ GSDGC 646_ KTPKL 651_ IEKLQ 656_ DLDVV 661_ KVRCG 666_ SQFSI 671_ ALTKD 676_ GQVYS 681_ WGKGD 686_ NQRLG 691_ HGTEE 696_ HVRYP 701_ KLLEG 706_ LQGKK 711_ VIDVA 716_ AGSTH 721_ CLALT 726_ EDSEV 731_ HSWGS 736_ NDQCQ 741_ HFDTL 746_ RVTKP 751_ EPAAL 756_ PGLDT 761_ KHIVG 766_ IACGP 771_ AQSFA 776_ WSSCS 781_ EWSIG 786_ LRVPF 791_ VVDIC 796_ SMTFE 801_ QLDLL 806_ LRQVS 811_ EGMDG 816_ SADWP 821_ PPQEK 826_ ECVAV 831_ ATLNL 836_ LRLQL 841_ HAAIS 846_ HQVDP 851_ EFLGL 856_ GLGSI 861_ LLNSL 866_ KQTVV 871_ TLASS 876_ AGVLS 881_ TVQSA 886_ AQAVL 891_ QSGWS 896_ VLLPT 901_ AEERA 906_ RALSA 911_ LLPCA 916_ VSGNE 921_ VNISP 926_ GRRFM 931_ IDLLV 936_ GSLMA 941_ DGGLE 946_ SALHA 951_ AITAE 956_ IQDIE 961_ AKKEA 966_ QKEKE 971_ IDEQE 976_ ANAST 981_ FHRSR 986_ TPLDK 991_ DLINT 996_ GICES 1001_ SGKQC 1006_ LPLVQ 1011_ LIQQL 1016_ LRNIA 1021_ SQTVA 1026_ RLKDV 1031_ ARRIS 1036_ SCLDF 1041_ EQHSR 1046_ ERSAS 1051_ LDLLL 1056_ RFQRL 1061_ LISKL 1066_ YPGES 1071_ IGQTS 1076_ DISSP 1081_ ELMGV 1086_ GSLLK 1091_ KYTAL 1096_ LCTHI 1101_ GDILP 1106_ VAASI 1111_ ASTSW 1116_ RHFAE 1121_ VAYIV 1126_ EGDFT 1131_ GVLLP 1136_ ELVVS 1141_ IVLLL 1146_ SKNAG 1151_ LMQEA 1156_ GAVPL 1161_ LGGLL 1166_ EHLDR 1171_ FNHLA 1176_ PGKER 1181_ DDHEE 1186_ LAWPG 1191_ IMESF 1196_ FTGQN 1201_ CRNNE 1206_ EVTLI 1211_ RKADL 1216_ ENHNK 1221_ DGGFW 1226_ TVIDG 1231_ KVYDI 1236_ KDFQT 1241_ QSLTG 1246_ NSILA 1251_ QFAGE 1256_ DPVVA 1261_ LEAAL 1266_ QFEDT 1271_ RESMH 1276_ AFCVG 1281_ QYLEP 1286_ DQEIV 1291_ TIPDL 1296_ GSLSS 1301_ PLIDT 1306_ ERNLG 1311_ LLLGL 1316_ HASYL 1321_ AMSTP 1326_ LSPVE 1331_ IECAK 1336_ WLQSS 1341_ IFSGG 1346_ LQTSQ 1351_ IHYSY 1356_ NEEKD 1361_ EDHCS 1366_ SPGGT 1371_ PASKS 1376_ RLCSH 1381_ RRALG 1386_ DHSQA 1391_ FLQAI 1396_ ADNNI 1401_ QDHNV 1406_ KDFLC 1411_ QIERY 1416_ CRQCH 1421_ LTTPI 1426_ MFPPE 1431_ HPVEE 1436_ VGRLL 1441_ LCCLL 1446_ KHEDL 1451_ GHVAL 1456_ SLVHA 1461_ GALGI 1466_ EQVKH 1471_ RTLPK 1476_ SVVDV 1481_ CRVVY 1486_ QAKCS 1491_ LIKTH 1496_ QEQGR 1501_ SYKEV 1506_ CAPVI 1511_ ERLRF 1516_ LFNEL 1521_ RPAVC 1526_ NDLSI 1531_ MSKFK 1536_ LLSSL 1541_ PRWRR 1546_ IAQKI 1551_ IRERR 1556_ KKRVP 1561_ KKPES 1566_ TDDEE 1571_ KIGNE 1576_ ESDLE 1581_ EACIL 1586_ PHSPI 1591_ NVDKR 1596_ PIAIK 1601_ SPKDK 1606_ WQPLL 1611_ STVTG 1616_ VHKYK 1621_ WLKQN 1626_ VQGLY 1631_ PQSPL 1636_ LSTIA 1641_ EFALK 1646_ EEPVD 1651_ VEKMR 1656_ KCLLK 1661_ QLERA 1666_ EVRLE 1671_ GIDTI 1676_ LKLAS 1681_ KNFLL 1686_ PSVQY 1691_ AMFCG 1696_ WQRLI 1701_ PEGID 1706_ IGEPL 1711_ TDCLK 1716_ DVDLI 1721_ PPFNR 1726_ MLLEV 1731_ TFGKL 1736_ YAWAV 1741_ QNIRN 1746_ VLMDA 1751_ SAKFK 1756_ ELGIQ 1761_ PVPLQ 1766_ TITNE 1771_ NPSGP 1776_ SLGTI 1781_ PQARF 1786_ LLVML 1791_ SMLTL 1796_ QHGAN 1801_ NLDLL 1806_ LNSGM 1811_ LALTQ 1816_ TALRL 1821_ IGPSC 1826_ DNVEE 1831_ DMNAS 1836_ AQGAS 1841_ ATVLE 1846_ ETRKE 1851_ TAPVQ 1856_ LPVSG 1861_ PELAA 1866_ MMKIG 1871_ TRVMR 1876_ GVDWK 1881_ WGDQD 1886_ GPPPG 1891_ LGRVI 1896_ GELGE 1901_ DGWIR 1906_ VQWDT 1911_ GSTNS 1916_ YRMGK 1921_ EGKYD 1926_ LKLAE 1931_ LPAAA 1936_ QPSAE 1941_ DSDTE 1946_ DDSEA 1951_ EQTER 1956_ NIHPT 1961_ AMMFT 1966_ STINL 1971_ LQTLC 1976_ LSAGV 1981_ HAEIM 1986_ QSEAT 1991_ KTLCG 1996_ LLRML 2001_ VESGT 2006_ TDKTS 2011_ SPNRL 2016_ VYREQ 2021_ HRSWC 2026_ TLGFV 2031_ RSIAL 2036_ TPQVC 2041_ GALSS 2046_ PQWIT 2051_ LLMKV 2056_ VEGHA 2061_ PFTAT 2066_ SLQRQ 2071_ ILAVH 2076_ LLQAV 2081_ LPSWD 2086_ KTERA 2091_ RDMKC 2096_ LVEKL 2101_ FDFLG 2106_ SLLTT 2111_ CSSDV 2116_ PLLRE 2121_ STLRR 2126_ RRVRP 2131_ QASLT 2136_ ATHSS 2141_ TLAEE 2146_ VVALL 2151_ RTLHS 2156_ LTQWN 2161_ GLINK 2166_ YINSQ 2171_ LRSIT 2176_ HSFVG 2181_ RPSEG 2186_ AQLED 2191_ YFPDS 2196_ ENPEV 2201_ GGLMA 2206_ VLAVI 2211_ GGIDG 2216_ RLRLG 2221_ GQVMH 2226_ DEFGE 2231_ GTVTR 2236_ ITPKG 2241_ KITVQ 2246_ FSDMR 2251_ TCRVC 2256_ PLNQL 2261_ KPLPA 2266_ VAFNV 2271_ NNLPF 2276_ TEPML 2281_ SVWAQ 2286_ LVNLA 2291_ GSKLE 2296_ KHKIK 2301_ KSTKQ 2306_ AFAGQ 2311_ VDLDL 2316_ LRCQQ 2321_ LKLYI 2326_ LKAGR 2331_ ALLSH 2336_ QDKLR 2341_ QILSQ 2346_ PAVQE 2351_ TGTVH 2356_ TDDGA 2361_ VVSPD 2366_ LGDMS 2371_ PEGPQ 2376_ PPMIL 2381_ LQQLL 2386_ ASATQ 2391_ PSPVK 2396_ AIFDK 2401_ QELEA 2406_ AALAV 2411_ CQCLA 2416_ VESTH 2421_ PSSPG 2426_ FEDCS 2431_ SSEAT 2436_ TPVAV 2441_ QHIRP 2446_ ARVKR 2451_ RKQSP 2456_ VPALP 2461_ IVVQL 2466_ MEMGF 2471_ SRRNI 2476_ EFALK 2481_ SLTGA 2486_ SGNAS 2491_ SLPGV 2496_ EALVG 2501_ WLLDH 2506_ SDIQV 2511_ TELSD 2516_ ADTVS 2521_ DEYSD 2526_ EEVVE 2531_ DVDDA 2536_ AYSMS 2541_ TGAVV 2546_ TESQT 2551_ YKKRA 2556_ DFLSN 2561_ DDYAV 2566_ YVREN 2571_ IQVGM 2576_ MVRCC 2581_ RAYEE 2586_ VCEGD 2591_ VGKVI 2596_ KLDRD 2601_ GLHDL 2606_ NVQCD 2611_ WQQKG 2616_ GTYWV 2621_ RYIHV 2626_ ELIGY 2631_ PPPSS 2636_ SSHIK 2641_ IGDKV 2646_ RVKAS 2651_ VTTPK 2656_ YKWGS 2661_ VTHQS 2666_ VGVVK 2671_ AFSAN 2676_ GKDII 2681_ VDFPQ 2686_ QSHWT 2691_ GLLSE 2696_ MELVP 2701_ SIHPG 2706_ VTCDG 2711_ CQMFP 2716_ INGSR 2721_ FKCRN 2726_ CDDFD 2731_ FCETC 2736_ FKTKK 2741_ HNTRH 2746_ TFGRI 2751_ NEPGQ 2756_ SAVFC 2761_ GRSGK 2766_ QLKRC 2771_ HSSQP 2776_ GMLLD 2781_ SWSRM 2786_ VKSLN 2791_ VSSSV 2796_ NQASR 2801_ LIDGS 2806_ EPCWQ 2811_ SSGSQ 2816_ GKHWI 2821_ RLEIF 2826_ PDVLV 2831_ HRLKM 2836_ IVDPA 2841_ DSSYM 2846_ PSLVV 2851_ VSGGN 2856_ SLNNL 2861_ IELKT 2866_ ININP 2871_ SDTTV 2876_ PLLND 2881_ CTEYH 2886_ RYIEI 2891_ AIKQC 2896_ RSSGI 2901_ DCKIH 2906_ GLILL 2911_ GRIRA 2916_ EEEDL 2921_ AAVPF 2926_ LASDN 2931_ EEEED 2936_ EKGNS 2941_ GSLIR 2946_ KKAAG 2951_ LESAA 2956_ TIRTK 2961_ VFVWG 2966_ LNDKD 2971_ QLGGL 2976_ KGSKI 2981_ KVPSF 2986_ SETLS 2991_ ALNVV 2996_ QVAGG 3001_ SKSLF 3006_ AVTVE 3011_ GKVYA 3016_ CGEAT 3021_ NGRLG 3026_ LGISS 3031_ GTVPI 3036_ PRQIT 3041_ ALSSY 3046_ VVKKV 3051_ AVHSG 3056_ GRHAT 3061_ ALTVD 3066_ GKVFS 3071_ WGEGD 3076_ DGKLG 3081_ HFSRM 3086_ NCDKP 3091_ RLIEA 3096_ LKTKR 3101_ IRDIA 3106_ CGSSH 3111_ SAALT 3116_ SSGEL 3121_ YTWGL 3126_ GEYGR 3131_ LGHGD 3136_ NTTQL 3141_ KPKMV 3146_ KVLLG 3151_ HRVIQ 3156_ VACGS 3161_ RDAQT 3166_ LALTD 3171_ EGLVF 3176_ SWGDG 3181_ DFGKL 3186_ GRGGS 3191_ EGCNI 3196_ PQNIE 3201_ RLNGQ 3206_ GVCQI 3211_ ECGAQ 3216_ FSLAL 3221_ TKSGV 3226_ VWTWG 3231_ KGDYF 3236_ RLGHG 3241_ SDVHV 3246_ RKPQV 3251_ VEGLR 3256_ GKKIV 3261_ HVAVG 3266_ ALHCL 3271_ AVTDS 3276_ GQVYA 3281_ WGDND 3286_ HGQQG 3291_ NGTTT 3296_ VNRKP 3301_ TLVQG 3306_ LEGQK 3311_ ITRVA 3316_ CGSSH 3321_ SVAWT 3326_ TVDVA 3331_ TPSVH 3336_ EPVLF 3341_ QTARD 3346_ PLGAS 3351_ YLGVP 3356_ SDADS 3361_ SAASN 3366_ KISGA 3371_ SNSKP 3376_ NRPSL 3381_ AKILL 3386_ SLDGN 3391_ LAKQQ 3396_ ALSHI 3401_ LTALQ 3406_ IMYAR 3411_ DAVVG 3416_ ALMPA 3421_ AMIAP 3426_ VECPS 3431_ FSSAA 3436_ PSDAS 3441_ AMASP 3446_ MNGEE 3451_ CMLAV 3456_ DIEDR 3461_ LSPNP 3466_ WQEKR 3471_ EIVSS 3476_ EDAVT 3481_ PSAVT 3486_ PSAPS 3491_ ASARP 3496_ FIPVT 3501_ DDLGA 3506_ ASIIA 3511_ ETMTK 3516_ TKEDV 3521_ ESQNK 3526_ AAGPE 3531_ PQALD 3536_ EFTSL 3541_ LIADD 3546_ TRVVV 3551_ DLLKL 3556_ SVCSR 3561_ AGDRG 3566_ RDVLS 3571_ AVLSG 3576_ MGTAY 3581_ PQVAD 3586_ MLLEL 3591_ CVTEL 3596_ EDVAT 3601_ DSQSG 3606_ RLSSQ 3611_ PVVVE 3616_ SSHPY 3621_ TDDTS 3626_ TSGTV 3631_ KIPGA 3636_ EGLRV 3641_ EFDRQ 3646_ CSTER 3651_ RHDPL 3656_ TVMDG 3661_ VNRIV 3666_ SVRSG 3671_ REWSD 3676_ WSSEL 3681_ RIPGD 3686_ ELKWK 3691_ FISDG 3696_ SVNGW 3701_ GWRFT 3706_ VYPIM 3711_ PAAGP 3716_ KELLS 3721_ DRCVL 3726_ SCPSM 3731_ DLVTC 3736_ LLDFR 3741_ LNLAS 3746_ NRSIV 3751_ PRLAA 3756_ SLAAC 3761_ AQLSA 3766_ LAASH 3771_ RMWAL 3776_ QRLRK 3781_ LLTTE 3786_ FGQSI 3791_ NINRL 3796_ LGEND 3801_ GETRA 3806_ LSFTG 3811_ SALAA 3816_ LVKGL 3821_ PEALQ 3826_ RQFEY 3831_ EDPIV 3836_ RGGKQ 3841_ LLHSP 3846_ FFKVL 3851_ VALAC 3856_ DLELD 3861_ TLPCC 3866_ AETHK 3871_ WAWFR 3876_ RYCMA 3881_ SRVAV 3886_ ALDKR 3891_ TPLPR 3896_ LFLDE 3901_ VAKKI 3906_ RELMA 3911_ DSENM 3916_ DVLHE 3921_ SHDIF 3926_ KREQD 3931_ EQLVQ 3936_ WMNRR 3941_ PDDWT 3946_ LSAGG 3951_ SGTIY 3956_ GWGHN 3961_ HRGQL 3966_ GGIEG 3971_ AKVKV 3976_ PTPCE 3981_ ALATL 3986_ RPVQL 3991_ IGGEQ 3996_ TLFAV 4001_ TADGK 4006_ LYATG 4011_ YGAGG 4016_ RLGIG 4021_ GTESV 4026_ STPTL 4031_ LESIQ 4036_ HVFIK 4041_ KVAVN 4046_ SGGKH 4051_ CLALS 4056_ SEGEV 4061_ YSWGE 4066_ AEDGK 4071_ LGHGN 4076_ RSPCD 4081_ RPRVI 4086_ ESLRG 4091_ IEVVD 4096_ VAAGG 4101_ AHSAC 4106_ VTAAG 4111_ DLYTW 4116_ GKGRY 4121_ GRLGH 4126_ SDSED 4131_ QLKPK 4136_ LVEAL 4141_ QGHRV 4146_ VDIAC 4151_ GSGDA 4156_ QTLCL 4161_ TDDDT 4166_ VWSWG 4171_ DGDYG 4176_ KLGRG 4181_ GSDGC 4186_ KVPMK 4191_ IDSLT 4196_ GLGVV 4201_ KVECG 4206_ SQFSV 4211_ ALTKS 4216_ GAVYT 4221_ WGKGD 4226_ YHRLG 4231_ HGSDD 4236_ HVRRP 4241_ RQVQG 4246_ LQGKK 4251_ VIAIA 4256_ TGSLH 4261_ CVCCT 4266_ EDGEV 4271_ YTWGD 4276_ NDEGQ 4281_ LGDGT 4286_ TNAIQ 4291_ RPRLV 4296_ AALQG 4301_ KKVNR 4306_ VACGS 4311_ AHTLA 4316_ WSTSK 4321_ PASAG 4326_ KLPAQ 4331_ VPMEY 4336_ NHLQE 4341_ IPIIA 4346_ LRNRL 4351_ LLLHH 4356_ LSELF 4361_ CPCIP 4366_ MFDLE 4371_ GSLDE 4376_ TGLGP 4381_ SVGFD 4386_ TLRGI 4391_ LISQG 4396_ KEAAF 4401_ RKVVQ 4406_ ATMVR 4411_ DRQHG 4416_ PVVEL 4421_ NRIQV 4426_ KRSRS 4431_ KGGLA 4436_ GPDGT 4441_ KSVFG 4446_ QMCAK 4451_ MSSFG 4456_ PDSLL 4461_ LPHRV 4466_ WKVKF 4471_ VGESV 4476_ DDCGG 4481_ GYSES 4486_ IAEIC 4491_ EELQN 4496_ GLTPL 4501_ LIVTP 4506_ NGRDE 4511_ SGANR 4516_ DCYLL 4521_ SPAAR 4526_ APVHS 4531_ SMFRF 4536_ LGVLL 4541_ GIAIR 4546_ TGSPL 4551_ SLNLA 4556_ EPVWK 4561_ QLAGM 4566_ SLTIA 4571_ DLSEV 4576_ DKDFI 4581_ PGLMY 4586_ IRDNE 4591_ ATSEE 4596_ FEAMS 4601_ LPFTV 4606_ PSASG 4611_ QDIQL 4616_ SSKHT 4621_ HITLD 4626_ NRAEY 4631_ VRLAI 4636_ NYRLH 4641_ EFDEQ 4646_ VAAVR 4651_ EGMAR 4656_ VVPVP 4661_ LLSLF 4666_ TGYEL 4671_ ETMVC 4676_ GSPDI 4681_ PLHLL 4686_ KSVAT 4691_ YKGIE 4696_ PSASL 4701_ IQWFW 4706_ EVMES 4711_ FSNTE 4716_ RSLFL 4721_ RFVWG 4726_ RTRLP 4731_ RTIAD 4736_ FRGRD 4741_ FVIQV 4746_ LDKYN 4751_ PPDHF 4756_ LPESY 4761_ TCFFL 4766_ LKLPR 4771_ YSCKQ 4776_ VLEEK 4781_ LKYAI 4786_ HFCKS 4791_ IDTDD 4796_ YARIA 4801_ LTGEP 4806_ AADDS 4811_ SDDSD 4816_ NEDVD 4821_ SFASD 4826_STQDY
1: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179)