Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
1_MSSDD 6_ RHLGS 11_ SCGSF 16_ IKTEP 21_ SSPSS 26_ GIDAL 31_ SHHSP 36_ SGSSD 41_ ASGGF 46_ GLALG 51_ THANG 56_ LDSPP 61_ MFAGA 66_ GLGGT 71_ PCRKS 76_ YEDCA 81_ SGIME 86_ DSAIK 91_ CEYML 96_ NAIPK 101_ RLCLV 106_ CGDIA 111_ SGYHY 116_ GVASC 121_ EACKA 126_ FFKRT 131_ IQGNI 136_ EYSCP 141_ ATNEC 146_ EITKR 151_ RRKSC 156_ QACRF 161_ MKCLK 166_ VGMLK 171_ EGVRL 176_ DRVRG 181_ GRQKY 186_ KRRLD 191_ SESSP 196_ YLSLQ 201_ ISPPA 206_ KKPLT 211_ KIVSY 216_ LLVAE 221_ PDKLY 226_ AMPPP 231_ GMPEG 236_ DIKAL 241_ TTLCD 246_ LADRE 251_ LVVII 256_ GWAKH 261_ IPGFS 266_ SLSLG 271_ DQMSL 276_ LQSAW 281_ MEILI 286_ LGIVY 291_ RSLPY 296_ DDKLV 301_ YAEDY 306_ IMDEE 311_ HSRLA 316_ GLLEL 321_ YRAIL 326_ QLVRR 331_ YKKLK 336_ VEKEE 341_ FVTLK 346_ ALALA 351_ NSDSM 356_ YIEDL 361_ EAVQK 366_ LQDLL 371_ HEALQ 376_ DYELS 381_ QRHEE 386_ PWRTG 391_ KLLLT 396_ LPLLR 401_ QTAAK 406_ AVQHF 411_ YSVKL 416_ QGKVP 421_ MHKLF 426_LEMLE
1: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Involved in morula development (2-16 cells embryos) by acting as a regulator at the 8-cell stage (By similarity). Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity)
2: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation