Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355)
1_MWWRV 6_ LSLLA 11_ WFPLQ 16_ EASLT 21_ NHTET 26_ ITVEE 31_ GQTLT 36_ LKCVT 41_ SLRKN 46_ SSLQW 51_ LTPSG 56_ FTIFL 61_ NEYPA 66_ LKNSK 71_ YQLLH 76_ HSANQ 81_ LSITV 86_ PNVTL 91_ QDEGV 96_ YKCLH 101_ YSDSV 106_ STKEV 111_ KVIVL 116_ ATPFK 121_ PILEA 126_ SVIRK 131_ QNGEE 136_ HVVLM 141_ CSTMR 146_ SKPPP 151_ QITWL 156_ LGNSM 161_ EVSGG 166_ TLHEF 171_ ETDGK 176_ KCNTT 181_ STLII 186_ HTYGK 191_ NSTVD 196_ CIIRH 201_ RGLQG 206_ RKLVA 211_ PFRFE 216_ DLVTD 221_ EETAS 226_ DALER 231_ NSLSS 236_ QDPQQ 241_ PTSTV 246_ SVTED 251_ SSTSE 256_ IDKEE 261_ KEQTT 266_ QDPDL 271_ TTEAN 276_ PQYLG 281_ LARKK 286_ SGILL 291_ LTLVS 296_ FLIFI 301_ LFIIV 306_ QLFIM 311_ KLRKA 316_ HVIWK 321_ KENEV 326_ SEHTL 331_ ESYRS 336_ RSNNE 341_ ETSSE 346_ EKNGQ 351_ SSHPM 356_ RCMNY 361_ ITKLY 366_ SEAKT 371_ KRKEN 376_ VQHSK 381_ LEEKH 386_IQVPE
1: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity)