AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
1_MPAVS 6_ KGDGM 11_ RGLAV 16_ FISDI 21_ RNCKS 26_ KEAEI 31_ KRINK 36_ ELANI 41_ RSKFK 46_ GDKAL 51_ DGYSK 56_ KKYVC 61_ KLLFI 66_ FLLGH 71_ DIDFG 76_ HMEAV 81_ NLLSS 86_ NKYTE 91_ KQIGY 96_ LFISV 101_ LVNSN 106_ SELIR 111_ LINNA 116_ IKNDL 121_ ASRNP 126_ TFMCL 131_ ALHCI 136_ ANVGS 141_ REMGE 146_ AFAAD 151_ IPRIL 156_ VAGDS 161_ MDSVK 166_ QSAAL 171_ CLLRL 176_ YKASP 181_ DLVPM 186_ GEWTA 191_ RVVHL 196_ LNDQH 201_ MGVVT 206_ AAVSL 211_ ITCLC 216_ KKNPD 221_ DFKTC 226_ VSLAV 231_ SRLSR 236_ IVSSA 241_ STDLQ 246_ DYTYY 251_ FVPAP 256_ WLSVK 261_ LLRLL 266_ QCYPP 271_ PEDAA 276_ VKGRL 281_ VECLE 286_ TVLNK 291_ AQEPP 296_ KSKKV 301_ QHSNA 306_ KNAIL 311_ FETIS 316_ LIIHY 321_ DSEPN 326_ LLVRA 331_ CNQLG 336_ QFLQH 341_ RETNL 346_ RYLAL 351_ ESMCT 356_ LASSE 361_ FSHEA 366_ VKTHI 371_ DTVIN 376_ ALKTE 381_ RDVSV 386_ RQRAA 391_ DLLYA 396_ MCDRS 401_ NAKQI 406_ VSEML 411_ RYLET 416_ ADYAI 421_ REEIV 426_ LKVAI 431_ LAEKY 436_ AVDYS 441_ WYVDT 446_ ILNLI 451_ RIAGD 456_ YVSEE 461_ VWYRV 466_ LQIVT 471_ NRDDV 476_ QGYAA 481_ KTVFE 486_ ALQAP 491_ ACHEN 496_ MVKVG 501_ GYILG 506_ EFGNL 511_ IAGDP 516_ RSSPP 521_ VQFSL 526_ LHSKF 531_ HLCSV 536_ ATRAL 541_ LLSTY 546_ IKFIN 551_ LFPET 556_ KATIQ 561_ GVLRA 566_ GSQLR 571_ NADVE 576_ LQQRA 581_ VEYLT 586_ LSSVA 591_ STDVL 596_ ATVLE 601_ EMPPF 606_ PERES 611_ SILAK 616_ LKRKK 621_ GPGAG 626_ SALDD 631_ GRRDP 636_ SSNDI 641_ NGGME 646_ PTPST 651_ VSTPS 656_ PSADL 661_ LGLRA 666_ APPPA 671_ APPAS 676_ AGAGN 681_ LLVDV 686_ FDGPA 691_ AQPSL 696_ GPTPE 701_ EAFLS 706_ ELEPP 711_ APESP 716_ MALLA 721_ DPAPA 726_ ADPGP 731_ EDIGP 736_ PIPEA 741_ DELLN 746_ KFVCK 751_ NNGVL 756_ FENQL 761_ LQIGV 766_ KSEFR 771_ QNLGR 776_ MYLFY 781_ GNKTS 786_ VQFQN 791_ FSPTV 796_ VHPGD 801_ LQTQL 806_ AVQTK 811_ RVAAQ 816_ VDGGA 821_ QVQQV 826_ LNIEC 831_ LRDFL 836_ TPPLL 841_ SVRFR 846_ YGGAP 851_ QALTL 856_ KLPVT 861_ INKFF 866_ QPTEM 871_ AAQDF 876_ FQRWK 881_ QLSLP 886_ QQEAQ 891_ KIFKA 896_ NHPMD 901_ AEVTK 906_ AKLLG 911_ FGSAL 916_ LDNVD 921_ PNPEN 926_ FVGAG 931_ IIQTK 936_ ALQVG 941_ CLLRL 946_ EPNAQ 951_ AQMYR 956_ LTLRT 961_ SKEPV 966_ SRHLC 971_ELLAQ
1: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity)