Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
1_MTTEQ 6_ RRSLQ 11_ AFQDY 16_ IRKTL 21_ DPTYI 26_ LSYMA 31_ PWFRE 36_ EEVQY 41_ IQAEK 46_ NNKGP 51_ MEAAT 56_ LFLKF 61_ LLELQ 66_ EEGWF 71_ RGFLD 76_ ALDHA 81_ GYSGL 86_ YEAIE 91_ SWDFK 96_ KIEKL 101_ EEYRL 106_ LLKRL 111_ QPEFK 116_ TRIIP 121_ TDIIS 126_ DLSEC 131_ LINQE 136_ CEEIL 141_ QICST 146_ KGMMA 151_ GAEKL 156_ VECLL 161_ RSDKE 166_ NWPKT 171_ LKLAL 176_ EKERN 181_ KFSEL 186_ WIVEK 191_ GIKDV 196_ ETEDL 201_ EDKME 206_ TSDIQ 211_ IFYQE 216_ DPECQ 221_ NLSEN 226_ SCPPS 231_ EVSDT 236_ NLYSP 241_ FKPRN 246_ YQLEL 251_ ALPAM 256_ KGKNT 261_ IICAP 266_ TGCGK 271_ TFVSL 276_ LICEH 281_ HLKKF 286_ PQGQK 291_ GKVVF 296_ FANQI 301_ PVYEQ 306_ QKSVF 311_ SKYFE 316_ RHGYR 321_ VTGIS 326_ GATAE 331_ NVPVE 336_ QIVEN 341_ NDIII 346_ LTPQI 351_ LVNNL 356_ KKGTI 361_ PSLSI 366_ FTLMI 371_ FDECH 376_ NTSKQ 381_ HPYNM 386_ IMFNY 391_ LDQKL 396_ GGSSG 401_ PLPQV 406_ IGLTA 411_ SVGVG 416_ DAKNT 421_ DEALD 426_ YICKL 431_ CASLD 436_ ASVIA 441_ TVKHN 446_ LEELE 451_ QVVYK 456_ PQKFF 461_ RKVES 466_ RISDK 471_ FKYII 476_ AQLMR 481_ DTESL 486_ AKRIC 491_ KDLEN 496_ LSQIQ 501_ NREFG 506_ TQKYE 511_ QWIVT 516_ VQKAC 521_ MVFQM 526_ PDKDE 531_ ESRIC 536_ KALFL 541_ YTSHL 546_ RKYND 551_ ALIIS 556_ EHARM 561_ KDALD 566_ YLKDF 571_ FSNVR 576_ AAGFD 581_ EIEQD 586_ LTQRF 591_ EEKLQ 596_ ELESV 601_ SRDPS 606_ NENPK 611_ LEDLC 616_ FILQE 621_ EYHLN 626_ PETIT 631_ ILFVK 636_ TRALV 641_ DALKN 646_ WIEGN 651_ PKLSF 656_ LKPGI 661_ LTGRG 666_ KTNQN 671_ TGMTL 676_ PAQKC 681_ ILDAF 686_ KASGD 691_ HNILI 696_ ATSVA 701_ DEGID 706_ IAQCN 711_ LVILY 716_ EYVGN 721_ VIKMI 726_ QTRGR 731_ GRARG 736_ SKCFL 741_ LTSNA 746_ GVIEK 751_ EQINM 756_ YKEKM 761_ MNDSI 766_ LRLQT 771_ WDEAV 776_ FREKI 781_ LHIQT 786_ HEKFI 791_ RDSQE 796_ KPKPV 801_ PDKEN 806_ KKLLC 811_ RKCKA 816_ LACYT 821_ ADVRV 826_ IEECH 831_ YTVLG 836_ DAFKE 841_ CFVSR 846_ PHPKP 851_ KQFSS 856_ FEKRA 861_ KIFCA 866_ RQNCS 871_ HDWGI 876_ HVKYK 881_ TFEIP 886_ VIKIE 891_ SFVVE 896_ DIATG 901_ VQTLY 906_ SKWKD 911_ FHFEK 916_IPFDP
1: Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:24366338, PubMed:28469175, PubMed:29117565, PubMed:31006531, PubMed:34935440, PubMed:35263596, PubMed:36793726). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.74). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration