Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)]
1_MSFIM 6_ KLHRH 11_ FQRTV 16_ ILLAT 21_ FCMVS 26_ IIISA 31_ YYLYS 36_ GYKQE 41_ NELSE 46_ TASEV 51_ DCGDL 56_ QHLPY 61_ QLMEV 66_ KAMKL 71_ FDASR 76_ TDPTV 81_ LVFVE 86_ SQYSS 91_ LGQDI 96_ IMILE 101_ SSRFQ 106_ YHIEI 111_ APGKG 116_ DLPVL 121_ IDKMK 126_ GKYIL 131_ IIYEN 136_ ILKYI 141_ NMDSW 146_ NRSLL 151_ DKYCV 156_ EYGVG 161_ VIGFH 166_ KTSEK 171_ SVQSF 176_ QLKGF 181_ PFSIY 186_ GNLAV 191_ KDCCI 196_ NPHSP 201_ LIRVT 206_ KSSKL 211_ EKGSL 216_ PGTDW 221_ TVFQI 226_ NHSAY 231_ QPVIF 236_ AKVKT 241_ PENLS 246_ PSISK 251_ GAFYA 256_ TIIHD 261_ LGLHD 266_ GIQRV 271_ LFGNN 276_ LNFWL 281_ HKLIF 286_ IDAIS 291_ FLSGK 296_ RLTLS 301_ LDRYI 306_ LVDID 311_ DIFVG 316_ KEGTR 321_ MNTND 326_ VKALL 331_ DTQNL 336_ LRAQI 341_ TNFTF 346_ NLGFS 351_ GKFYH 356_ TGTEE 361_ EDEGD 366_ DCLLG 371_ SVDEF 376_ WWFPH 381_ MWSHM 386_ QPHLF 391_ HNESS 396_ LVEQM 401_ ILNKK 406_ FALEH 411_ GIPTD 416_ MGYAV 421_ APHHS 426_ GVYPV 431_ HVQLY 436_ EAWKK 441_ VWNIK 446_ ITSTE 451_ EYPHL 456_ KPARY 461_ RRGFI 466_ HKNIM 471_ VLPRQ 476_ TCGLF 481_ THTIF 486_ YKEYP 491_ GGPKE 496_ LDKSI 501_ QGGEL 506_ FFTVV 511_ LNPIS 516_ IFMTH 521_ LSNYG 526_ NDRLG 531_ LYTFV 536_ NLANF 541_ VKSWT 546_ NLRLQ 551_ TLPPV 556_ QLAHK 561_ YFELF 566_ PDQKD 571_ PLWQN 576_ PCDDK 581_ RHRDI 586_ WSKEK 591_ TCDRL 596_ PKFLV 601_ IGPQK 606_ TGTTA 611_ LYLFL 616_ VMHPS 621_ ILSNS 626_ PSPKT 631_ FEEVQ 636_ FFNRN 641_ NYHRG 646_ IDWYM 651_ DFFPV 656_ PSNVT 661_ TDFLF 666_ EKSAN 671_ YFHSE 676_ EAPKR 681_ AASLV 686_ PKAKI 691_ ITILI 696_ DPSDR 701_ AYSWY 706_ QHQRS 711_ HEDPA 716_ ALKFS 721_ FYEVI 726_ SAGPR 731_ APSEL 736_ RALQK 741_ RCLVP 746_ GWYAS 751_ HIERW 756_ LVYFP 761_ PFQLL 766_ IIDGQ 771_ QLRTD 776_ PATVM 781_ DEVQK 786_ FLGVL 791_ PHYNY 796_ SEALT 801_ FDSHK 806_ GFWCQ 811_ LLEEG 816_ KTKCL 821_ GKSKG 826_ RKYPP 831_ MDSDS 836_ RTFLS 841_ SYYRD 846_ HNVEL 851_ SKLLH 856_ KLGQP 861_ LPSWL 866_RQELQ
1: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity