BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
1_MSAAT 6_ HSPMM 11_ QVASG 16_ NGDRD 21_ PLPPG 26_ WEIKI 31_ DPQTG 36_ WPFFV 41_ DHNSR 46_ TTTWN 51_ DPRVP 56_ SEGPK 61_ ETPSS 66_ ANGPS 71_ REGSR 76_ LPPAR 81_ EGHPV 86_ YPQLR 91_ PGYIP 96_ IPVLH 101_ EGAEN 106_ RQVHP 111_ FHVYP 116_ QPGMQ 121_ RFRTE 126_ AAAAA 131_ PQRSQ 136_ SPLRG 141_ MPETT 146_ QPDKQ 151_ CGQVA 156_ AAAAA 161_ QPPAS 166_ HGPER 171_ SQSPA 176_ ASDCS 181_ SSSSS 186_ ASLPS 191_ SGRSS 196_ LGSHQ 201_ LPRGY 206_ ISIPV 211_ IHEQN 216_ VTRPA 221_ AQPSF 226_ HQAQK 231_ THYPA 236_ QQGEY 241_ QTHQP 246_ VYHKI 251_ QGDDW 256_ EPRPL 261_ RAASP 266_ FRSSV 271_ QGASS 276_ REGSP 281_ ARSST 286_ PLHSP 291_ SPIRV 296_ HTVVD 301_ RPQQP 306_ MTHRE 311_ TAPVS 316_ QPENK 321_ PESKP 326_ GPVGP 331_ ELPPG 336_ HIPIQ 341_ VIRKE 346_ VDSKP 351_ VSQKP 356_ PPPSE 361_ KVEVK 366_ VPPAP 371_ VPCPP 376_ PSPGP 381_ SAVPS 386_ SPKSV 391_ ATEER 396_ AAPST 401_ APAEA 406_ TPPKP 411_ GEAEA 416_ PPKHP 421_ GVLKV 426_ EAILE 431_ KVQGL 436_ EQAVD 441_ NFEGK 446_ KTDKK 451_ YLMIE 456_ EYLTK 461_ ELLAL 466_ DSVDP 471_ EGRAD 476_ VRQAR 481_ RDGVR 486_ KVQTI 491_ LEKLE 496_ QKAID 501_ VPGQV 506_ QVYEL 511_ QPSNL 516_ EADQP 521_ LQAIM 526_ EMGAV 531_ AADKG 536_ KKNAG 541_ NAEDP 546_ HTETQ 551_ QPEAT 556_ AAATS 561_ NPSSM 566_TDTPG
1: Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920)