Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
1_MANDS 6_ PAKSL 11_ VDIDL 16_ SSLRD 21_ PAGIF 26_ ELVEV 31_ VGNGT 36_ YGQVY 41_ KGRHV 46_ KTGQL 51_ AAIKV 56_ MDVTE 61_ DEEEE 66_ IKLEI 71_ NMLKK 76_ YSHHR 81_ NIATY 86_ YGAFI 91_ KKSPP 96_ GHDDQ 101_ LWLVM 106_ EFCGA 111_ GSITD 116_ LVKNT 121_ KGNTL 126_ KEDWI 131_ AYISR 136_ EILRG 141_ LAHLH 146_ IHHVI 151_ HRDIK 156_ GQNVL 161_ LTENA 166_ EVKLV 171_ DFGVS 176_ AQLDR 181_ TVGRR 186_ NTFIG 191_ TPYWM 196_ APEVI 201_ ACDEN 206_ PDATY 211_ DYRSD 216_ LWSCG 221_ ITAIE 226_ MAEGA 231_ PPLCD 236_ MHPMR 241_ ALFLI 246_ PRNPP 251_ PRLKS 256_ KKWSK 261_ KFFSF 266_ IEGCL 271_ VKNYM 276_ QRPST 281_ EQLLK 286_ HPFIR 291_ DQPNE 296_ RQVRI 301_ QLKDH 306_ IDRTR 311_ KKRGE 316_ KDETE 321_ YEYSG 326_ SEEEE 331_ EEVPE 336_ QEGEP 341_ SSIVN 346_ VPGES 351_ TLRRD 356_ FLRLQ 361_ QENKE 366_ RSEAL 371_ RRQQL 376_ LQEQQ 381_ LREQE 386_ EYKRQ 391_ LLAER 396_ QKRIE 401_ QQKEQ 406_ RRRLE 411_ EQQRR 416_ EREAR 421_ RQQER 426_ EQRRR 431_ EQEEK 436_ RRLEE 441_ LERRR 446_ KEEEE 451_ RRRAE 456_ EEKRR 461_ VEREQ 466_ EYIRR 471_ QLEEE 476_ QRHLE 481_ VLQQQ 486_ LLQEQ 491_ AMLLE 496_ CRWRE 501_ MEEHR 506_ QAERL 511_ QRQLQ 516_ QEQAY 521_ LLSLQ 526_ HDHRR 531_ PHPQH 536_ SQQPP 541_ PPQQE 546_ RSKPS 551_ FHAPE 556_ PKAHY 561_ EPADR 566_ AREVE 571_ DRFRK 576_ TNHSS 581_ PEAQS 586_ KQTGR 591_ VLEPP 596_ VPSRS 601_ ESFSN 606_ GNSES 611_ VHPAL 616_ QRPAE 621_ PQVPV 626_ RTTSR 631_ SPVLS 636_ RRDSP 641_ LQGSG 646_ QQNSQ 651_ AGQRN 656_ STSIE 661_ PRLLW 666_ ERVEK 671_ LVPRP 676_ GSGSS 681_ SGSSN 686_ SGSQP 691_ GSHPG 696_ SQSGS 701_ GERFR 706_ VRSSS 711_ KSEGS 716_ PSQRL 721_ ENAVK 726_ KPEDK 731_ KEVFR 736_ PLKPA 741_ DLTAL 746_ AKELR 751_ AVEDV 756_ RPPHK 761_ VTDYS 766_ SSSEE 771_ SGTTD 776_ EEDDD 781_ VEQEG 786_ ADEST 791_ SGPED 796_ TRAAS 801_ SLNLS 806_ NGETE 811_ SVKTM 816_ IVHDD 821_ VESEP 826_ AMTPS 831_ KEGTL 836_ IVRQT 841_ QSASS 846_ TLQKH 851_ KSSSS 856_ FTPFI 861_ DPRLL 866_ QISPS 871_ SGTTV 876_ TSVVG 881_ FSCDG 886_ MRPEA 891_ IRQDP 896_ TRKGS 901_ VVNVN 906_ PTNTR 911_ PQSDT 916_ PEIRK 921_ YKKRF 926_ NSEIL 931_ CAALW 936_ GVNLL 941_ VGTES 946_ GLMLL 951_ DRSGQ 956_ GKVYP 961_ LINRR 966_ RFQQM 971_ DVLEG 976_ LNVLV 981_ TISGK 986_ KDKLR 991_ VYYLS 996_ WLRNK 1001_ ILHND 1006_ PEVEK 1011_ KQGWT 1016_ TVGDL 1021_ EGCVH 1026_ YKVVK 1031_ YERIK 1036_ FLVIA 1041_ LKSSV 1046_ EVYAW 1051_ APKPY 1056_ HKFMA 1061_ FKSFG 1066_ ELVHK 1071_ PLLVD 1076_ LTVEE 1081_ GQRLK 1086_ VIYGS 1091_ CAGFH 1096_ AVDVD 1101_ SGSVY 1106_ DIYLP 1111_ THIQC 1116_ SIKPH 1121_ AIIIL 1126_ PNTDG 1131_ MELLV 1136_ CYEDE 1141_ GVYVN 1146_ TYGRI 1151_ TKDVV 1156_ LQWGE 1161_ MPTSV 1166_ AYIRS 1171_ NQTMG 1176_ WGEKA 1181_ IEIRS 1186_ VETGH 1191_ LDGVF 1196_ MHKRA 1201_ QRLKF 1206_ LCERN 1211_ DKVFF 1216_ ASVRS 1221_ GGSSQ 1226_ VYFMT 1231_LGRTS
1: Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). Phosphorylates SMAD1 on Thr-322 (PubMed:21690388)