Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)
1_MRGFG 6_ PGLTA 11_ RRLLP 16_ LRLPP 21_ RPPGP 26_ RLASG 31_ QAAGA 36_ LERAM 41_ DELLR 46_ RAVPP 51_ TPAYE 56_ LREKT 61_ PAPAE 66_ GQCAD 71_ FVSFY 76_ GGLAE 81_ TAQRA 86_ ELLGR 91_ LARGF 96_ GVDHG 101_ QVAEQ 106_ SAGVL 111_ HLRQQ 116_ QREAA 121_ VLLQA 126_ EDRLR 131_ YALVP 136_ RYRGL 141_ FHHIS 146_ KLDGG 151_ VRFLV 156_ QLRAD 161_ LLEAQ 166_ ALKLV 171_ EGPDV 176_ REMNG 181_ VLKGM 186_ LSEWF 191_ SSGFL 196_ NLERV 201_ TWHSP 206_ CEVLQ 211_ KISEA 216_ EAVHP 221_ VKNWM 226_ DMKRR 231_ VGPYR 236_ RCYFF 241_ SHCST 246_ PGEPL 251_ VVLHV 256_ ALTGD 261_ ISSNI 266_ QAIVK 271_ EHPPS 276_ ETEEK 281_ NKITA 286_ AIFYS 291_ ISLTQ 296_ QGLQG 301_ VELGT 306_ FLIKR 311_ VVKEL 316_ QREFP 321_ HLGVF 326_ SSLSP 331_ IPGFT 336_ KWLLG 341_ LLNSQ 346_ TKEHG 351_ RNELF 356_ TDSEC 361_ KEISE 366_ ITGGP 371_ INETL 376_ KLLLS 381_ SSEWV 386_ QSEKL 391_ VRALQ 396_ TPLMR 401_ LCAWY 406_ LYGEK 411_ HRGYA 416_ LNPVA 421_ NFHLQ 426_ NGAVL 431_ WRINW 436_ MADVS 441_ LRGIT 446_ GSCGL 451_ MANYR 456_ YFLEE 461_ TGPNS 466_ TSYLG 471_ SKIIK 476_ ASEQV 481_ LSLVA 486_QFQKN
1: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation