Chloride intracellular channel protein 3
1_MAETK 6_ LQLFV 11_ KASED 16_ GESVG 21_ HCPSC 26_ QRLFM 31_ VLLLK 36_ GVPFT 41_ LTTVD 46_ TRRSP 51_ DVLKD 56_ FAPGS 61_ QLPIL 66_ LYDSD 71_ AKTDT 76_ LQIED 81_ FLEET 86_ LGPPD 91_ FPSLA 96_ PRYRE 101_ SNTAG 106_ NDVFH 111_ KFSAF 116_ IKNPV 121_ PAQDE 126_ ALYQQ 131_ LLRAL 136_ ARLDS 141_ YLRAP 146_ LEHEL 151_ AGEPQ 156_ LRESR 161_ RRFLD 166_ GDRLT 171_ LADCS 176_ LLPKL 181_ HIVDT 186_ VCAHF 191_ RQAPI 196_ PAELR 201_ GVRRY 206_ LDSAM 211_ QEKEF 216_ KYTCP 221_ HSAEI 226_ LAAYR 231_PAVHP
1: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:28198360, PubMed:37759794). Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (PubMed:28198360). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control