Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
1_MKRSE 6_ KPEGY 11_ RQMRP 16_ KTFPA 21_ SNYTV 26_ SSRQM 31_ LQEIR 36_ ESLRN 41_ LSKPS 46_ DAAKA 51_ EHNMS 56_ KMSTE 61_ DPRQV 66_ RNPPK 71_ FGTHH 76_ KALQE 81_ IRNSL 86_ LPFAN 91_ ETNSS 96_ RSTSE 101_ VNPQM 106_ LQDLQ 111_ AAGFD 116_ EDMVI 121_ QALQK 126_ TNNRS 131_ IEAAI 136_ EFISK 141_ MSYQD 146_ PRREQ 151_ MAAAA 156_ ARPIN 161_ ASMKP 166_ GNVQQ 171_ SVNRK 176_ QSWKG 181_ SKESL 186_ VPQRH 191_ GPPLG 196_ ESVAY 201_ HSESP 206_ NSQTD 211_ VGRPL 216_ SGSGI 221_ SAFVQ 226_ AHPSN 231_ GQRVN 236_ PPPPP 241_ QVRSV 246_ TPPPP 251_ PRGQT 256_ PPPRG 261_ TTPPP 266_ PSWEP 271_ NSQTK 276_ RYSGN 281_ MEYVI 286_ SRISP 291_ VPPGA 296_ WQEGY 301_ PPPPL 306_ NTSPM 311_ NPPNQ 316_ GQRGI 321_ SSVPV 326_ GRQPI 331_ IMQSS 336_ SKFNF 341_ PSGRP 346_ GMQNG 351_ TGQTD 356_ FMIHQ 361_ NVVPA 366_ GTVNR 371_ QPPPP 376_ YPLTA 381_ ANGQS 386_ PSALQ 391_ TGGSA 396_ APSSY 401_ TNGSI 406_ PQSMM 411_ VPNRN 416_ SHNME 421_ LYNIS 426_ VPGLQ 431_ TNWPQ 436_ SSSAP 441_ AQSSP 446_ SSGHE 451_ IPTWQ 456_ PNIPV 461_ RSNSF 466_ NNPLG 471_ NRASH 476_ SANSQ 481_ PSATT 486_ VTAIT 491_ PAPIQ 496_ QPVKS 501_ MRVLK 506_ PELQT 511_ ALAPT 516_ HPSWI 521_ PQPIQ 526_ TVQPS 531_ PFPEG 536_ TASNV 541_ TVMPP 546_ VAEAP 551_ NYQGP 556_ PPPYP 561_ KHLLH 566_ QNPSV 571_ PPYES 576_ ISKPS 581_ KEDQP 586_ SLPKE 591_ DESEK 596_ SYENV 601_ DSGDK 606_ EKKQI 611_ TTSPI 616_ TVRKN 621_ KKDEE 626_ RRESR 631_ IQSYS 636_ PQAFK 641_ FFMEQ 646_ HVENV 651_ LKSHQ 656_ QRLHR 661_ KKQLE 666_ NEMMR 671_ VGLSQ 676_ DAQDQ 681_ MRKML 686_ CQKES 691_ NYIRL 696_ KRAKM 701_ DKSMF 706_ VKIKT 711_ LGIGA 716_ FGEVC 721_ LARKV 726_ DTKAL 731_ YATKT 736_ LRKKD 741_ VLLRN 746_ QVAHV 751_ KAERD 756_ ILAEA 761_ DNEWV 766_ VRLYY 771_ SFQDK 776_ DNLYF 781_ VMDYI 786_ PGGDM 791_ MSLLI 796_ RMGIF 801_ PESLA 806_ RFYIA 811_ ELTCA 816_ VESVH 821_ KMGFI 826_ HRDIK 831_ PDNIL 836_ IDRDG 841_ HIKLT 846_ DFGLC 851_ TGFRW 856_ THDSK 861_ YYQSG 866_ DHPRQ 871_ DSMDF 876_ SNEWG 881_ DPSSC 886_ RCGDR 891_ LKPLE 896_ RRAAR 901_ QHQRC 906_ LAHSL 911_ VGTPN 916_ YIAPE 921_ VLLRT 926_ GYTQL 931_ CDWWS 936_ VGVIL 941_ FEMLV 946_ GQPPF 951_ LAQTP 956_ LETQM 961_ KVINW 966_ QTSLH 971_ IPPQA 976_ KLSPE 981_ ASDLI 986_ IKLCR 991_ GPEDR 996_ LGKNG 1001_ ADEIK 1006_ AHPFF 1011_ KTIDF 1016_ SSDLR 1021_ QQSAS 1026_ YIPKI 1031_ THPTD 1036_ TSNFD 1041_ PVDPD 1046_ KLWSD 1051_ DNEEE 1056_ NVNDT 1061_ LNGWY 1066_ KNGKH 1071_ PEHAF 1076_ YEFTF 1081_ RRFFD 1086_ DNGYP 1091_ YNYPK 1096_ PIEYE 1101_ YINSQ 1106_ GSEQQ 1111_ SDEDD 1116_ QNTGS 1121_EIKNR
1: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637)