Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27)
1_MSVPE 6_ EEERL 11_ LPLTQ 16_ RWPRA 21_ SKFLL 26_ SGCAA 31_ TVAEL 36_ ATFPL 41_ DLTKT 46_ RLQMQ 51_ GEAAL 56_ ARLGD 61_ GARES 66_ APYRG 71_ MVRTA 76_ LGIIE 81_ EEGFL 86_ KLWQG 91_ VTPAI 96_ YRHVV 101_ YSGGR 106_ MVTYE 111_ HLREV 116_ VFGKS 121_ EDEHY 126_ PLWKS 131_ VIGGM 136_ MAGVI 141_ GQFLA 146_ NPTDL 151_ VKVQM 156_ QMEGK 161_ RKLEG 166_ KPLRF 171_ RGVHH 176_ AFAKI 181_ LAEGG 186_ IRGLW 191_ AGWVP 196_ NIQRA 201_ ALVNM 206_ GDLTT 211_ YDTVK 216_ HYLVL 221_ NTPLE 226_ DNIMT 231_ HGLSS 236_ LCSGL 241_ VASIL 246_ GTPAD 251_ VIKSR 256_ IMNQP 261_ RDKQG 266_ RGLLY 271_ KSSTD 276_ CLIQA 281_ VQGEG 286_ FMSLY 291_ KGFLP 296_ SWLRM 301_ TPWSM 306_ VFWLT 311_ YEKIR 316_EMSGV
1: Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated