Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15)
1_MPRGD 6_ SEQVR 11_ YCARF 16_ SYLWL 21_ KFSLI 26_ IYSTV 31_ FWLIG 36_ ALVLS 41_ VGIYA 46_ EVERQ 51_ KYKTL 56_ ESAFL 61_ APAII 66_ LILLG 71_ VVMFM 76_ VSFIG 81_ VLASL 86_ RDNLY 91_ LLQAF 96_ MYILG 101_ ICLIM 106_ ELIGG 111_ VVALT 116_ FRNQT 121_ IDFLN 126_ DNIRR 131_ GIENY 136_ YDDLD 141_ FKNIM 146_ DFVQK 151_ KFKCC 156_ GGEDY 161_ RDWSK 166_ NQYHD 171_ CSAPG 176_ PLACG 181_ VPYTC 186_ CIRNT 191_ TEVVN 196_ TMCGY 201_ KTIDK 206_ ERFSV 211_ QDVIY 216_ VRGCT 221_ NAVII 226_ WFMDN 231_ YTIMA 236_ GILLG 241_ ILLPQ 246_ FLGVL 251_ LTLLY 256_ ITRVE 261_ DIIME 266_ HSVTD 271_ GLLGP 276_ GAKPS 281_ VEAAG 286_TGCCL
1: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:30463011, PubMed:31792032, PubMed:34739841). Promotes ADAM10-mediated cleavage of CDH2 (PubMed:34739841). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862, PubMed:31792032)