Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12)
1_MARED 6_ SVKCL 11_ RCLLY 16_ ALNLL 21_ FWLMS 26_ ISVLA 31_ VSAWM 36_ RDYLN 41_ NVLTL 46_ TAETR 51_ VEEAV 56_ ILTYF 61_ PVVHP 66_ VMIAV 71_ CCFLI 76_ IVGML 81_ GYCGT 86_ VKRNL 91_ LLLAW 96_ YFGSL 101_ LVIFC 106_ VELAC 111_ GVWTY 116_ EQELM 121_ VPVQW 126_ SDMVT 131_ LKARM 136_ TNYGL 141_ PRYRW 146_ LTHAW 151_ NFFQR 156_ EFKCC 161_ GVVYF 166_ TDWLE 171_ MTEMD 176_ WPPDS 181_ CCVRE 186_ FPGCS 191_ KQAHQ 196_ EDLSD 201_ LYQEG 206_ CGKKM 211_ YSFLR 216_ GTKQL 221_ QVLRF 226_ LGISI 231_ GVTQI 236_ LAMIL 241_ TITLL 246_ WALYY 251_ DRREP 256_ GTDQM 261_ MSLKN 266_ DNSQH 271_ LSCPS 276_ VELLK 281_ PSLSR 286_ IFEHT 291_ SMANS 296_FNTHF
1: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity