3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)
1_MASSN 6_ TVLMR 11_ LVASA 16_ YSIAQ 21_ KAGMI 26_ VRRVI 31_ AEGDL 36_ GIVEK 41_ TCATD 46_ LQTKA 51_ DRLAQ 56_ MSICS 61_ SLARK 66_ FPKLT 71_ IIGEE 76_ DLPSE 81_ EVDQE 86_ LIEDS 91_ QWEEI 96_ LKQPC 101_ PSQYS 106_ AIKEE 111_ DLVVW 116_ VDPLD 121_ GTKEY 126_ TEGLL 131_ DNVTV 136_ LIGIA 141_ YEGKA 146_ IAGVI 151_ NQPYY 156_ NYEAG 161_ PDAVL 166_ GRTIW 171_ GVLGL 176_ GAFGF 181_ QLKEV 186_ PAGKH 191_ IITTT 196_ RSHSN 201_ KLVTD 206_ CVAAM 211_ NPDAV 216_ LRVGG 221_ AGNKI 226_ IQLIE 231_ GKASA 236_ YVFAS 241_ PGCKK 246_ WDTCA 251_ PEVIL 256_ HAVGG 261_ KLTDI 266_ HGNVL 271_ QYHKD 276_ VKHMN 281_ SAGVL 286_ ATLRN 291_ YDYYA 296_ SRVPE 301_SIKNA
1: Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate (PubMed:10675562). Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate (PubMed:10675562)