Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2)
1_MGKGG 6_ NQGEG 11_ AAERE 16_ VSVPT 21_ FSWEE 26_ IQKHN 31_ LRTDR 36_ WLVID 41_ RKVYN 46_ ITKWS 51_ IQHPG 56_ GQRVI 61_ GHYAG 66_ EDATD 71_ AFRAF 76_ HPDLE 81_ FVGKF 86_ LKPLL 91_ IGELA 96_ PEEPS 101_ QDHGK 106_ NSKIT 111_ EDFRA 116_ LRKTA 121_ EDMNL 126_ FKTNH 131_ VFFLL 136_ LLAHI 141_ IALES 146_ IAWFT 151_ VFYFG 156_ NGWIP 161_ TLITA 166_ FVLAT 171_ SQAQA 176_ GWLQH 181_ DYGHL 186_ SVYRK 191_ PKWNH 196_ LVHKF 201_ VIGHL 206_ KGASA 211_ NWWNH 216_ RHFQH 221_ HAKPN 226_ IFHKD 231_ PDVNM 236_ LHVFV 241_ LGEWQ 246_ PIEYG 251_ KKKLK 256_ YLPYN 261_ HQHEY 266_ FFLIG 271_ PPLLI 276_ PMYFQ 281_ YQIIM 286_ TMIVH 291_ KNWVD 296_ LAWAV 301_ SYYIR 306_ FFITY 311_ IPFYG 316_ ILGAL 321_ LFLNF 326_ IRFLE 331_ SHWFV 336_ WVTQM 341_ NHIVM 346_ EIDQE 351_ AYRDW 356_ FSSQL 361_ TATCN 366_ VEQSF 371_ FNDWF 376_ SGHLN 381_ FQIEH 386_ HLFPT 391_ MPRHN 396_ LHKIA 401_ PLVKS 406_ LCAKH 411_ GIEYQ 416_ EKPLL 421_ RALLD 426_ IIRSL 431_ KKSGK 436_LWLDA
1: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity (PubMed:12713571). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity)