N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC 3.5.3.18) (DDAHII) (Dimethylargininase-2) (Protein G6a) (S-phase protein)
1_MGTPG 6_ EGLGR 11_ CSHAL 16_ IRGVP 21_ ESLAS 26_ GEGAG 31_ AGLPA 36_ LDLAK 41_ AQREH 46_ GVLGG 51_ KLRQR 56_ LGLQL 61_ LELPP 66_ EESLP 71_ LGPLL 76_ GDTAV 81_ IQGDT 86_ ALITR 91_ PWSPA 96_ RRPEV 101_ DGVRK 106_ ALQDL 111_ GLRIV 116_ EIGDE 121_ NATLD 126_ GTDVL 131_ FTGRE 136_ FFVGL 141_ SKWTN 146_ HRGAE 151_ IVADT 156_ FRDFA 161_ VSTVP 166_ VSGPS 171_ HLRGL 176_ CGMGG 181_ PRTVV 186_ AGSSD 191_ AAQKA 196_ VRAMA 201_ VLTDH 206_ PYASL 211_ TLPDD 216_ AAADC 221_ LFLRP 226_ GLPGV 231_ PPFLL 236_ HRGGG 241_ DLPNS 246_ QEALQ 251_ KLSDV 256_ TLVPV 261_ SCSEL 266_ EKAGA 271_ GLSSL 276_CLVLS
1: Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055)