Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b)
1_MAVFL 6_ QLLPL 11_ LLSRA 16_ QGNPG 21_ ASLDG 26_ RPGDR 31_ VNLSC 36_ GGVSH 41_ PIRWV 46_ WAPSF 51_ PACKG 56_ LSKGR 61_ RPILW 66_ ASSSG 71_ TPTVP 76_ PLQPF 81_ VGRLR 86_ SLDSG 91_ IRRLE 96_ LLLSA 101_ GDSGT 106_ FFCKG 111_ RHEDE 116_ SRTVL 121_ HVLGD 126_ RTYCK 131_ APGPT 136_ HGSVY 141_ PQLLI 146_ PLLGA 151_ GLVLG 156_ LGALG 161_ LVWWL 166_ HRRLP 171_ PQPIR 176_ PLPRF 181_ APLVK 186_ TEPQR 191_ PVKEE 196_ EPKIP 201_ GDLDQ 206_ EPSLL 211_ YADLD 216_ HLALS 221_ RPRRL 226_ STADP 231_ ADAST 236_IYAVV
1: Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801)
2: Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B