Noelin-2 (Olfactomedin-2)
1_MWPLT 6_ VPPPL 11_ LLLLC 16_ SGLAG 21_ QTLFQ 26_ NPEEG 31_ WQLYT 36_ SAQAP 41_ DGKCI 46_ CTAVI 51_ PAQST 56_ CSRDG 61_ RSREL 66_ RQLME 71_ KVQNV 76_ SQSME 81_ VLELR 86_ TYRDL 91_ QYVRG 96_ METLM 101_ RSLDA 106_ RLRAA 111_ DGSLS 116_ AKSFQ 121_ ELKDR 126_ MTELL 131_ PLSSV 136_ LEQYK 141_ ADTRT 146_ IVRLR 151_ EEVRN 156_ LSGSL 161_ AAIQE 166_ EMGAY 171_ GYEDL 176_ QQRVM 181_ ALEAR 186_ LHACA 191_ QKLGC 196_ GKLTG 201_ VSNPI 206_ TVRAM 211_ GSRFG 216_ SWMTD 221_ TMAPS 226_ ADSRV 231_ WYMDG 236_ YYKGR 241_ RVLEF 246_ RTLGD 251_ FIKGQ 256_ NFIQH 261_ LLPQP 266_ WAGTG 271_ HVVYN 276_ GSLFY 281_ NKYQS 286_ NVVVK 291_ YHFRS 296_ RSVLV 301_ QRSLP 306_ GAGYN 311_ NTFPY 316_ SWGGF 321_ SDMDF 326_ MVDES 331_ GLWAV 336_ YTTNQ 341_ NAGNI 346_ VVSRL 351_ DPHTL 356_ EVMRS 361_ WDTGY 366_ PKRSA 371_ GEAFM 376_ ICGVL 381_ YVTNS 386_ HLAGA 391_ KVYFA 396_ YFTNT 401_ SSYEY 406_ TDVPF 411_ HNQYS 416_ HISML 421_ DYNPR 426_ ERALY 431_ TWNNG 436_ HQVLY 441_ NVTLF 446_HVIST
1: Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity)