Pseudouridylate synthase TRUB2, mitochondrial (EC 5.4.99.-) (TruB pseudouridine synthase homolog 2) (tRNA pseudouridine 55 synthase TRUB2) (Psi55 synthase TRUB2) (EC 5.4.99.25)
1_MGSAG 6_ LSRLH 11_ GLFAV 16_ YKPPG 21_ LKWKH 26_ LRDTV 31_ ELQLL 36_ KGLNA 41_ RKPPA 46_ PKQRV 51_ RFLLG 56_ PMEGS 61_ EEKEL 66_ TLTAT 71_ SVPSF 76_ INHPL 81_ VCGPA 86_ FAHLK 91_ VGVGH 96_ RLDAQ 101_ ASGVL 106_ VLGVG 111_ HGCRL 116_ LTDMY 121_ NAHLT 126_ KDYTV 131_ RGLLG 136_ KATDD 141_ FREDG 146_ RLVEK 151_ TTYDH 156_ VTREK 161_ LDRIL 166_ AVIQG 171_ SHQKA 176_ LVMYS 181_ NLDLK 186_ TQEAY 191_ EMAVR 196_ GLIRP 201_ MNKSP 206_ MLITG 211_ IRCLY 216_ FAPPE 221_ FLLEV 226_ QCMHE 231_ TQKEL 236_ RKLVH 241_ EIGLE 246_ LKTTA 251_ VCTQV 256_ RRTRD 261_ GFFTL 266_ DSALL 271_ RTQWD 276_ LTNIQ 281_ DAIRA 286_ ATPQV 291_ AAELE 296_ KSLSP 301_ GLDTK 306_ QLPSP 311_ GWSWD 316_ SQGPS 321_ STLGL 326_ERGAG
1: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933)