Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1)
1_MEETM 6_ KLATM 11_ EDTVE 16_ YCLFL 21_ IPDES 26_ RDSDK 31_ HKEIL 36_ QKYIE 41_ RIITR 46_ FAPML 51_ VPYIW 56_ QNQPF 61_ NLKYK 66_ PGKGG 71_ VPAHM 76_ FGVTK 81_ FGDNI 86_ EDEWF 91_ IVYVI 96_ KQITK 101_ EFPEL 106_ VARIE 111_ DNDGE 116_ FLLIE 121_ AADFL 126_ PKWLD 131_ PENST 136_ NRVFF 141_ CHGEL 146_ CIIPA 151_ PRKSG 156_ AESWL 161_ PTTPP 166_ TIPQA 171_ LNIIT 176_ AHSEK 181_ ILASE 186_ SIRAA 191_ VNRRI 196_ RGYPE 201_ KIQAS 206_ LHRAH 211_ CFLPA 216_ GIVAV 221_ LKQRP 226_ RLVAA 231_ AVQAF 236_ YLRDP 241_ IDLRA 246_ CRVFK 251_ TFLPE 256_ TRIMT 261_ SVTFT 266_ KCLYA 271_ QLVQQ 276_ RFVPD 281_ RRSGY 286_ RLPPP 291_ SDPQY 296_ RAHEL 301_ GMKLA 306_ HGFEI 311_ LCSKC 316_ SPHFS 321_ DCKKS 326_ LVTAS 331_ PLWAS 336_ FLESL 341_ KKNDY 346_ FKGLI 351_ EGSAQ 356_ YRERL 361_ EMAEN 366_ YFQLS 371_ VDWPE 376_ SSLAM 381_ SPGEE 386_ ILTLL 391_ QTIPF 396_ DIEDL 401_ KKEAA 406_ NLPPE 411_ DDDQW 416_ LDLSP 421_ DQLDQ 426_ LLQEA 431_ VGKKE 436_ SESVS 441_ KEEKE 446_ QNYDL 451_ TEVSE 456_ SMKAF 461_ ISKVS 466_ THKGA 471_ ELPRE 476_ PSEAP 481_ ITFDA 486_ DSFLN 491_ YFDKI 496_ LGPRP 501_ NESDS 506_ DDLDD 511_ EDFEC 516_ LDSDD 521_ DLDFE 526_ THEPG 531_ EEASL 536_ KGTLD 541_ NLKSY 546_ MAQMD 551_ QELAH 556_ TCISK 561_ SFTTR 566_ NQVEP 571_ VSQTT 576_ DNNSD 581_ EEDSG 586_ TGESV 591_ MAPVD 596_ VDLNL 601_ VSNIL 606_ ESYSS 611_ QAGLA 616_ GPASN 621_ LLQSM 626_ GVQLP 631_ DNTDH 636_RPTSK
1: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). Participates together with DDX39A in mRNA nuclear export (PubMed:33941617)