Polyglutamylase complex subunit TTLL1 (EC 6.3.2.-) (Tubulin polyglutamylase TTLL1) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1)
1_MAGKV 6_ KWVTD 11_ IEKSV 16_ LINNF 21_ EKRGW 26_ VQVTE 31_ NEDWN 36_ FYWMS 41_ VQTIR 46_ NVFSV 51_ EAGYR 56_ LSDDQ 61_ IVNHF 66_ PNHYE 71_ LTRKD 76_ LMVKN 81_ IKRYR 86_ KELEK 91_ EGSPL 96_ AEKDE 101_ NGKYL 106_ YLDFV 111_ PVTYM 116_ LPADY 121_ NLFVE 126_ EFRKS 131_ PSSTW 136_ IMKPC 141_ GKAQG 146_ KGIFL 151_ INKLS 156_ QIKKW 161_ SRDSK 166_ TSSFV 171_ SQSNK 176_ EAYVI 181_ SLYIN 186_ NPLLI 191_ GGRKF 196_ DLRLY 201_ VLVST 206_ YRPLR 211_ CYMYK 216_ LGFCR 221_ FCTVK 226_ YTPST 231_ SELDN 236_ MFVHL 241_ TNVAI 246_ QKHGE 251_ DYNHI 256_ HGGKW 261_ TVSNL 266_ RLYLE 271_ STRGK 276_ EVTSK 281_ LFDEI 286_ HWIIV 291_ QSLKA 296_ VAPVM 301_ NNDKH 306_ CFECY 311_ GYDII 316_ IDDKL 321_ KPWLI 326_ EVNAS 331_ PSLTS 336_ STAND 341_ RILKY 346_ NLIND 351_ TLNIA 356_ VPNGE 361_ IPDCK 366_ WNKSP 371_ PKEVL 376_ GNYEI 381_ LYDEE 386_ LAQGD 391_ GADRE 396_ LRSRQ 401_ GQSLG 406_ PRAGR 411_ SRDSG 416_RAVLT
1: Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:34782749). Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis