Chromobox protein homolog 7
1_MELSA 6_ IGEQV 11_ FAVES 16_ IRKKR 21_ VRKGK 26_ VEYLV 31_ KWKGW 36_ PPKYS 41_ TWEPE 46_ EHILD 51_ PRLVM 56_ AYEEK 61_ EERDR 66_ ASGYR 71_ KRGPK 76_ PKRLL 81_ LQRLY 86_ SMDLR 91_ SSHKA 96_ KGKEK 101_ LCFSL 106_ TCPLG 111_ SGSPE 116_ GVVKA 121_ GAPEL 126_ VDKGP 131_ LVPTL 136_ PFPLR 141_ KPRKA 146_ HKYLR 151_ LSRKK 156_ FPPRG 161_ PNLES 166_ HSHRR 171_ ELFLQ 176_ EPPAP 181_ DVLQA 186_ AGEWE 191_ PAAQP 196_ PEEEA 201_ DADLA 206_ EGPPP 211_ WTPAL 216_ PSSEV 221_ TVTDI 226_ TANSI 231_ TVTFR 236_ EAQAA 241_ EGFFR 246_DRSGK
1: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity