EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)
1_MLPCA 6_ SCLPG 11_ SLLLW 16_ ALLLL 21_ LLGSA 26_ SPQDS 31_ EEPDS 36_ YTECT 41_ DGYEW 46_ DPDSQ 51_ HCRDV 56_ NECLT 61_ IPEAC 66_ KGEMK 71_ CINHY 76_ GGYLC 81_ LPRSA 86_ AVIND 91_ LHGEG 96_ PPPPV 101_ PPAQH 106_ PNPCP 111_ PGYEP 116_ DDQDS 121_ CVDVD 126_ ECAQA 131_ LHDCR 136_ PSQDC 141_ HNLPG 146_ SYQCT 151_ CPDGY 156_ RKIGP 161_ ECVDI 166_ DECRY 171_ RYCQH 176_ RCVNL 181_ PGSFR 186_ CQCEP 191_ GFQLG 196_ PNNRS 201_ CVDVN 206_ ECDMG 211_ APCEQ 216_ RCFNS 221_ YGTFL 226_ CRCHQ 231_ GYELH 236_ RDGFS 241_ CSDID 246_ ECSYS 251_ SYLCQ 256_ YRCIN 261_ EPGRF 266_ SCHCP 271_ QGYQL 276_ LATRL 281_ CQDID 286_ ECESG 291_ AHQCS 296_ EAQTC 301_ VNFHG 306_ GYRCV 311_ DTNRC 316_ VEPYI 321_ QVSEN 326_ RCLCP 331_ ASNPL 336_ CREQP 341_ SSIVH 346_ RYMTI 351_ TSERS 356_ VPADV 361_ FQIQA 366_ TSVYP 371_ GAYNA 376_ FQIRA 381_ GNSQG 386_ DFYIR 391_ QINNV 396_ SAMLV 401_ LARPV 406_ TGPRE 411_ YVLDL 416_ EMVTM 421_ NSLMS 426_ YRASS 431_ VLRLT 436_VFVGA
1: Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta (PubMed:27339457). In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (By similarity). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction (PubMed:18973305, PubMed:19570982). Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling (PubMed:23782690)