Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)
1_MATVR 6_ ASLRG 11_ ALLLL 16_ LAVAG 21_ VAEVA 26_ GGLAP 31_ GSAGA 36_ LCCNH 41_ SKDNQ 46_ MCRDV 51_ CEQIF 56_ SSKSE 61_ SRLKH 66_ LLQRA 71_ PDYCP 76_ ETMVE 81_ IWNCM 86_ NSSLP 91_ GVFKK 96_ SDGWV 101_ GLGCC 106_ ELAIA 111_ LECRQ 116_ ACKQA 121_ SSKND 126_ ISKVC 131_ RKEYE 136_ NALFS 141_ CISRN 146_ EMGSV 151_ CCSYA 156_ GHHTN 161_ CREYC 166_ QAIFR 171_ TDSSP 176_ GPSQI 181_ KAVEN 186_ YCASI 191_ SPQLI 196_ HCVNN 201_ YTQSY 206_ PMRNP 211_ TDSLY 216_ CCDRA 221_ EDHAC 226_ QNACK 231_ RILMS 236_ KKTEM 241_ EIVDG 246_ LIEGC 251_ KTQPL 256_ PQDPL 261_ WQCFL 266_ ESSQS 271_ VHPGV 276_ TVHPP 281_ PSTGL 286_ DGAKL 291_ HCCSK 296_ ANTST 301_ CRELC 306_ TKLYS 311_ MSWGN 316_ TQSWQ 321_ EFDRF 326_ CEYNP 331_ VEVSM 336_ LTCLA 341_ DVREP 346_ CQLGC 351_ RNLTY 356_ CTNFN 361_ NRPTE 366_ LFRSC 371_ NAQSD 376_ QGAMN 381_ DMKLW 386_ EKGSI 391_ KMPFI 396_ NIPVL 401_ DIKKC 406_ QPEMW 411_ KAIAC 416_ SLQIK 421_ PCHSK 426_ SRGSI 431_ ICKSD 436_ CVEIL 441_ KKCGD 446_ QNKFP 451_ EDHTA 456_ ESICE 461_ LLSPT 466_ DDLKN 471_ CIPLD 476_ TYLRP 481_ STLGN 486_ IVEEV 491_ THPCN 496_ PNPCP 501_ ANELC 506_ EVNRK 511_ GCPSG 516_ DPCLP 521_ YFCVQ 526_ GCKLG 531_ EASDF 536_ IVRQG 541_ TLIQV 546_ PSSAG 551_ EVGCY 556_ KICSC 561_ GQSGL 566_ LENCM 571_ EMHCI 576_ DLQKS 581_ CIVGG 586_ KRKSH 591_ GTSFS 596_ IDCNV 601_ CSCFA 606_ GNLVC 611_ STRLC 616_ LSEHS 621_ SEDDR 626_ RTFTG 631_ LPCNC 636_ ADQFV 641_ PVCGQ 646_ NGRTY 651_ PSACI 656_ ARCVG 661_ LQDHQ 666_ FEFGS 671_ CMSKD 676_ PCNPN 681_ PCQKN 686_ QRCIP 691_ KPQVC 696_ LTTFD 701_ KFGCS 706_ QYECV 711_ PRQLA 716_ CDQVQ 721_ DPVCD 726_ TDHME 731_ HNNLC 736_ TLYQR 741_ GKSLS 746_ YKGPC 751_ QPFCR 756_ ATEPV 761_ CGHNG 766_ ETYSS 771_ VCAAY 776_ SDRVA 781_ VDYYG 786_ DCQAV 791_ GVLSE 796_ HSSVA 801_ ECASV 806_ KCPSL 811_ LAAGC 816_ KPIIP 821_ PGACC 826_ PLCAG 831_ MLRVL 836_ FDKEK 841_ LDTIA 846_ KVTNK 851_ KPITV 856_ LEILQ 861_ KIRMH 866_ VSVPQ 871_ CDVFG 876_ YFSIE 881_ SEIVI 886_ LIIPV 891_ DHYPK 896_ ALQIE 901_ ACNKE 906_ AEKIE 911_ SLINS 916_ DSPTL 921_ ASHVP 926_ LSALI 931_ ISQVQ 936_ VSSSV 941_ PSAGV 946_ RARPS 951_ CHSLL 956_ LPLSL 961_ GLALH 966_LLWTY
1: Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:18194466, PubMed:9789069). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069)