Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)
1_MERKR 6_ WECPA 11_ LPQGW 16_ EREEV 21_ PRRSG 26_ LSAGH 31_ RDVFY 36_ YSPSG 41_ KKFRS 46_ KPQLA 51_ RYLGG 56_ SMDLS 61_ TFDFR 66_ TGKML 71_ MSKMN 76_ KSRQR 81_ VRYDS 86_ SNQVK 91_ GKPDL 96_ NTALP 101_ VRQTA 106_ SIFKQ 111_ PVTKI 116_ TNHPS 121_ NKVKS 126_ DPQKA 131_ VDQPR 136_ QLFWE 141_ KKLSG 146_ LNAFD 151_ IAEEL 156_ VKTMD 161_ LPKGL 166_ QGVGP 171_ GCTDE 176_ TLLSA 181_ IASAL 186_ HTSTM 191_ PITGQ 196_ LSAAV 201_ EKNPG 206_ VWLNT 211_ TQPLC 216_ KAFMV 221_ TDEDI 226_ RKQEE 231_ LVQQV 236_ RKRLE 241_ EALMA 246_ DMLAH 251_ VEELA 256_ RDGEA 261_ PLDKA 266_ CAEDD 271_ DEEDE 276_ EEEEE 281_ EPDPD 286_PEMEH
1: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases