Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A)
1_MYSEI 6_ QRERA 11_ DIGGL 16_ MARPE 21_ YREWN 26_ PELIK 31_ PKKLL 36_ NPVKA 41_ SRSHQ 46_ ELHRE 51_ LLMNH 56_ RRGLG 61_ VDSKP 66_ ELQRV 71_ LEHRR 76_ RNQLI 81_ KKKKE 86_ ELEAK 91_ RLQCP 96_ FEQEL 101_ LRRQQ 106_ RLNQL 111_ EKPPE 116_ KEEDH 121_ APEFI 126_ KVREN 131_ LRRIA 136_TLTSE
1: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580)