Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)
1_MAPKK 6_ KGKKG 11_ KAKGT 16_ PIVDG 21_ LAPED 26_ MSKEQ 31_ VEEHV 36_ SRIRE 41_ ELDRE 46_ REERN 51_ YFQLE 56_ RDKIH 61_ TFWEI 66_ TRRQL 71_ EEKKA 76_ ELRNK 81_ DREME 86_ EAEER 91_ HQVEI 96_ KVYKQ 101_ KVKHL 106_ LYEHQ 111_ NNLTE 116_ MKAEG 121_ TVVMK 126_ LAQKE 131_ HRIQE 136_ SVLRK 141_ DMRAL 146_ KVELK 151_ EQELA 156_ SEVVV 161_ KNLRL 166_ KHTEE 171_ ITRMR 176_ NDFER 181_ QVREI 186_ EAKYD 191_ KKMKM 196_ LRDEL 201_ DLRRK 206_ TELHE 211_ VEERK 216_ NGQIH 221_ TLMQR 226_ HEEAF 231_ TDIKN 236_ YYNDI 241_ TLNNL 246_ ALINS 251_ LKEQM 256_ EDMRK 261_ KEDHL 266_ EREMA 271_ EVSGQ 276_ NKRLA 281_ DPLQK 286_ AREEM 291_ SEMQK 296_ QLANY 301_ ERDKQ 306_ ILLCT 311_ KARLK 316_ VREKE 321_ LKDLQ 326_ WEHEV 331_ LEQRF 336_ TKVQQ 341_ ERDEL 346_ YRKFT 351_ AAIQE 356_ VQQKT 361_ GFKNL 366_ VLERK 371_ LQALS 376_ AAVEK 381_ KEVQF 386_ NEVLA 391_ ASNLD 396_ PAALT 401_ LVSRK 406_ LEDVL 411_ ESKNS 416_ TIKDL 421_ QYELA 426_ QVCKA 431_ HNDLL 436_ RTYEA 441_ KLLAF 446_ GIPLD 451_ NVGFK 456_ PLETA 461_ VIGQT 466_ LGQGP 471_AGLVG
1: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity)