Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)
1_MTMRH 6_ NWTPD 11_ LSPLW 16_ VLLLC 21_ AHVVT 26_ LLVRA 31_ TPVSQ 36_ TTTAA 41_ TASVR 46_ STKDP 51_ CPSQP 56_ PVFPA 61_ AKQCP 66_ ALEVT 71_ WPEVE 76_ VPLNG 81_ TLSLS 86_ CVACS 91_ RFPNF 96_ SILYW 101_ LGNGS 106_ FIEHL 111_ PGRLW 116_ EGSTS 121_ RERGS 126_ TGTQL 131_ CKALV 136_ LEQLT 141_ PALHS 146_ TNFSC 151_ VLVDP 156_ EQVVQ 161_ RHVVL 166_ AQLWA 171_ GLRAT 176_ LPPTQ 181_ EALPS 186_SHSSP
1: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response