B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)
1_MEPTA 6_ PSLTE 11_ EDLTE 16_ VKKDA 21_ LENLR 26_ VYLCE 31_ KIIAE 36_ RHFDH 41_ LRAKK 46_ ILSRE 51_ DTEEI 56_ SCRTS 61_ SRKRA 66_ GKLLD 71_ YLQEN 76_ PKGLD 81_ TLVES 86_ IRREK 91_ TQNFL 96_ IQKIT 101_ DEVLK 106_ LRNIK 111_ LEHLK 116_ GLKCS 121_ SCEPF 126_ PDGAT 131_ NNLSR 136_ SNSDE 141_ SNFSE 146_ KLRAS 151_ TVMYH 156_ PEGES 161_ STTPF 166_ FSTNS 171_ SLNLP 176_ VLEVG 181_ RTENT 186_ IFSST 191_ TLPRP 196_ GDPGA 201_ PPLPP 206_ DLQLE 211_ EEGTC 216_ ANSSE 221_ MFLPL 226_RSRTV
1: Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815)