Heart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND)
1_MNLVG 6_ SYAHH 11_ HHHHH 16_ PHPAH 21_ PMLHE 26_ PFLFG 31_ PASRC 36_ HQERP 41_ YFQSW 46_ LLSPA 51_ DAAPD 56_ FPAGG 61_ PPPAA 66_ AAAAT 71_ AYGPD 76_ ARPGQ 81_ SPGRL 86_ EALGG 91_ RLGRR 96_ KGSGP 101_ KKERR 106_ RTESI 111_ NSAFA 116_ ELREC 121_ IPNVP 126_ ADTKL 131_ SKIKT 136_ LRLAT 141_ SYIAY 146_ LMDVL 151_ AKDAQ 156_ SGDPE 161_ AFKAE 166_ LKKAD 171_ GGRES 176_ KRKRE 181_ LQQHE 186_ GFPPA 191_ LGPVE 196_ KRIKG 201_ RTGWP 206_QQVWA
1: Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (PubMed:9931445)