E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)
1_MENKS 6_ LESSQ 11_ TDLKL 16_ VAHPR 21_ AKSKV 26_ WKYFG 31_ FDTNA 36_ EGCIL 41_ QWKKI 46_ YCRIC 51_ MAQIA 56_ YSGNT 61_ SNLSY 66_ HLEKN 71_ HPEEF 76_ CEFVK 81_ SNTEQ 86_ MREAF 91_ ATAFS 96_ KLKPE 101_ SSQQP 106_ GQDAL 111_ AVKAG 116_ HGYDS 121_ KKQQE 126_ LTAAV 131_ LGLIC 136_ EGLYP 141_ ASIVD 146_ EPTFK 151_ VLLKT 156_ ADPRY 161_ ELPSR 166_ KYIST 171_ KAIPE 176_ KYGAV 181_ REVIL 186_ KELAE 191_ ATWCG 196_ ISTDM 201_ WRSEN 206_ QNRAY 211_ VTLAA 216_ HFLGL 221_ GAPNC 226_ LSMGS 231_ RCLKT 236_ FEVPE 241_ ENTAE 246_ TITRV 251_ LYEVF 256_ IEWGI 261_ SAKVF 266_ GATTN 271_ YGKDI 276_ VKACS 281_ LLDVA 286_ VHMPC 291_ LGHTF 296_ NAGIQ 301_ QAFQL 306_ PKLGA 311_ LLSRC 316_ RKLVE 321_ YFQQS 326_ AVAMY 331_ MLYEK 336_ QKQQN 341_ VAHCM 346_ LVSNR 351_ VSWWG 356_ STLAM 361_ LQRLK 366_ EQQFV 371_ IAGVL 376_ VEDSN 381_ NHHLM 386_ LEASE 391_ WATIE 396_ GLVEL 401_ LQPFK 406_ QVAEM 411_ LSASR 416_ YPTIS 421_ MVKPL 426_ LHMLL 431_ NTTLN 436_ IKETD 441_ SKELS 446_ MAKEV 451_ IAKEL 456_ SKTYQ 461_ ETPEI 466_ DMFLN 471_ VATFL 476_ DPRYK 481_ RLPFL 486_ SAFER 491_ QQVEN 496_ RVVEE 501_ AKGLL 506_ DKVKD 511_ GGYRP 516_ AEDKI 521_ FPVPE 526_ EPPVK 531_ KLMRT 536_ STPPP 541_ ASVIN 546_ NMLAE 551_ IFCQT 556_ GGVED 561_ QEEWH 566_ AQVVE 571_ ELSNF 576_ KSQKV 581_ LGLNE 586_ DPLKW 591_ WSDRL 596_ ALFPL 601_ LPKVL 606_ QKYWC 611_ VTATR 616_ VAPER 621_ LFGSA 626_ ANVVS 631_ AKRNR 636_ LAPAH 641_ VDEQV 646_ FLYEN 651_ ARSGA 656_ EAEPE 661_ DQDEG 666_ EWGLD 671_ QEQVF 676_ SLGDG 681_ VSGGF 686_FGIRD
1: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747)
2: (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection