Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
1_MFGKR 6_ KKRVE 11_ ISAPS 16_ NFEHR 21_ VHTGF 26_ DQHEQ 31_ KFTGL 36_ PRQWQ 41_ SLIEE 46_ SARRP 51_ KPLVD 56_ PACIT 61_ SIQPG 66_ APKTI 71_ VRGSK 76_ GAKDG 81_ ALTLL 86_ LDEFE 91_ NMSVT 96_ RSNSL 101_ RRDSP 106_ PPPAR 111_ ARQEN 116_ GMPEE 121_ PATTA 126_ RGGPG 131_ KAGSR 136_ GRFAG 141_ HSEAG 146_ GGSGD 151_ RRRAG 156_ PEKRP 161_ KSSRE 166_ GSGGP 171_ QESSR 176_ DKRPL 181_ SGPDV 186_ GTPQP 191_ AGLAS 196_ GAKLA 201_ AGRPF 206_ NTYPR 211_ ADTDH 216_ PSRGA 221_ QGEPH 226_ DVAPN 231_ GPSAG 236_ GLAIP 241_ QSSSS 246_ SSRPP 251_ TRARG 256_ APSPG 261_ VLGPH 266_ ASEPQ 271_ LAPPA 276_ CTPAA 281_ PAVPG 286_ PPGPR 291_ SPQRE 296_ PQRVS 301_ HEQFR 306_ AALQL 311_ VVDPG 316_ DPRSY 321_ LDNFI 326_ KIGEG 331_ STGIV 336_ CIATV 341_ RSSGK 346_ LVAVK 351_ KMDLR 356_ KQQRR 361_ ELLFN 366_ EVVIM 371_ RDYQH 376_ ENVVE 381_ MYNSY 386_ LVGDE 391_ LWVVM 396_ EFLEG 401_ GALTD 406_ IVTHT 411_ RMNEE 416_ QIAAV 421_ CLAVL 426_ QALSV 431_ LHAQG 436_ VIHRD 441_ IKSDS 446_ ILLTH 451_ DGRVK 456_ LSDFG 461_ FCAQV 466_ SKEVP 471_ RRKSL 476_ VGTPY 481_ WMAPE 486_ LISRL 491_ PYGPE 496_ VDIWS 501_ LGIMV 506_ IEMVD 511_ GEPPY 516_ FNEPP 521_ LKAMK 526_ MIRDN 531_ LPPRL 536_ KNLHK 541_ VSPSL 546_ KGFLD 551_ RLLVR 556_ DPAQR 561_ ATAAE 566_ LLKHP 571_ FLAKA 576_ GPPAS 581_ IVPLM 586_RQNRT
1: Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620)