Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K)
1_MSGGV 6_ YGGDE 11_ VGALV 16_ FDIGS 21_ YTVRA 26_ GYAGE 31_ DCPKV 36_ DFPTA 41_ IGMVV 46_ ERDDG 51_ STLME 56_ IDGDK 61_ GKQGG 66_ PTYYI 71_ DTNAL 76_ RVPRE 81_ NMEAI 86_ SPLKN 91_ GMVED 96_ WDSFQ 101_ AILDH 106_ TYKMH 111_ VKSEA 116_ SLHPV 121_ LMSEA 126_ PWNTR 131_ AKREK 136_ LTELM 141_ FEHYN 146_ IPAFF 151_ LCKTA 156_ VLTAF 161_ ANGRS 166_ TGLIL 171_ DSGAT 176_ HTTAI 181_ PVHDG 186_ YVLQQ 191_ GIVKS 196_ PLAGD 201_ FITMQ 206_ CRELF 211_ QEMNI 216_ ELVPP 221_ YMIAS 226_ KEAVR 231_ EGSPA 236_ NWKRK 241_ EKLPQ 246_ VTRSW 251_ HNYMC 256_ NCVIQ 261_ DFQAS 266_ VLQVS 271_ DSTYD 276_ EQVAA 281_ QMPTV 286_ HYEFP 291_ NGYNC 296_ DFGAE 301_ RLKIP 306_ EGLFD 311_ PSNVK 316_ GLSGN 321_ TMLGV 326_ SHVVT 331_ TSVGM 336_ CDIDI 341_ RPGLY 346_ GSVIV 351_ AGGNT 356_ LIQSF 361_ TDRLN 366_ RELSQ 371_ KTPPS 376_ MRLKL 381_ IANNT 386_ TVERR 391_ FSSWI 396_ GGSIL 401_ ASLGT 406_ FQQMW 411_ ISKQE 416_ YEEGG 421_KQCVE
1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair