Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
1_MEFSI 6_ KQSPL 11_ SVQSV 16_ VKCIK 21_ MKQAP 26_ EILGS 31_ ANGKT 36_ PSCEV 41_ NRECS 46_ VFLSK 51_ AQLSS 56_ SLQEG 61_ VMQKF 66_ NGHDA 71_ LPFIP 76_ ADKLK 81_ DLTSR 86_ VFNGE 91_ PGAHD 96_ AKLRF 101_ ESQEM 106_ KGIGT 111_ PPNTT 116_ PIKNG 121_ SPEIK 126_ LKITK 131_ TYMNG 136_ KPLFE 141_ SSICG 146_ DSAAD 151_ VSQSE 156_ ENGQK 161_ PENKA 166_ RRNRK 171_ RSIKY 176_ DSLLE 181_ QGLVE 186_ AALVS 191_ KISSP 196_ SDKKI 201_ PAKKE 206_ SCPNT 211_ GRDKD 216_ HLLKY 221_ NVGDL 226_ VWSKV 231_ SGYPW 236_ WPCMV 241_ SADPL 246_ LHSYT 251_ KLKGQ 256_ KKSAR 261_ QYHVQ 266_ FFGDA 271_ PERAW 276_ IFEKS 281_ LVAFE 286_ GEGQF 291_ EKLCQ 296_ ESAKQ 301_ APTKA 306_ EKIKL 311_ LKPIS 316_ GKLRA 321_ QWEMG 326_ IVQAE 331_ EAASM 336_ SVEER 341_ KAKFT 346_ FLYVG 351_ DQLHL 356_ NPQVA 361_ KEAGI 366_ AAESL 371_ GEMAE 376_ SSGVS 381_ EEAAE 386_ NPKSV 391_ REECI 396_ PMKRR 401_ RRAKL 406_ CSSAE 411_ TLESH 416_ PDIGK 421_ STPQK 426_ TAEAD 431_ PRRGV 436_ GSPPG 441_ RKKTT 446_ VSMPR 451_ SRKGD 456_ AASQF 461_ LVFCQ 466_ KHRDE 471_ VVAEH 476_ PDASG 481_ EEIEE 486_ LLRSQ 491_ WSLLS 496_ EKQRA 501_ RYNTK 506_ FALVA 511_ PVQAE 516_ EDSGN 521_ VNGKK 526_ RNHTK 531_ RIQDP 536_ TEDAE 541_ AEDTP 546_ RKRLR 551_ TDKHS 556_ LRKRD 561_ TITDK 566_ TARTS 571_ SYKAM 576_ EAASS 581_ LKSQA 586_ ATKNL 591_ SDACK 596_ PLKKR 601_ NRAST 606_ AASSA 611_ LGFSK 616_ SSSPS 621_ ASLTE 626_ NEVSD 631_ SPGDE 636_ PSESP 641_ YESAD 646_ ETQTE 651_ VSVSS 656_ KKSER 661_ GVTAK 666_ KEYVC 671_ QLCEK 676_ PGSLL 681_ LCEGP 686_ CCGAF 691_ HLACL 696_ GLSRR 701_ PEGRF 706_ TCSEC 711_ ASGIH 716_ SCFVC 721_ KESKT 726_ DVKRC 731_ VVTQC 736_ GKFYH 741_ EACVK 746_ KYPLT 751_ VFESR 756_ GFRCP 761_ LHSCV 766_ SCHAS 771_ NPSNP 776_ RPSKG 781_ KMMRC 786_ VRCPV 791_ AYHSG 796_ DACLA 801_ AGCSV 806_ IASNS 811_ IICTA 816_ HFTAR 821_ KGKRH 826_ HAHVN 831_ VSWCF 836_ VCSKG 841_ GSLLC 846_ CESCP 851_ AAFHP 856_ DCLNI 861_ EMPDG 866_ SWFCN 871_ DCRAG 876_ KKLHF 881_ QDIIW 886_ VKLGN 891_ YRWWP 896_ AEVCH 901_ PKNVP 906_ PNIQK 911_ MKHEI 916_ GEFPV 921_ FFFGS 926_ KDYYW 931_ THQAR 936_ VFPYM 941_ EGDRG 946_ SRYQG 951_ VRGIG 956_ RVFKN 961_ ALQEA 966_ EARFR 971_ EIKLQ 976_ REARE 981_ TQESE 986_ RKPPP 991_ YKHIK 996_ VNKPY 1001_ GKVQI 1006_ YTADI 1011_ SEIPK 1016_ CNCKP 1021_ TDENP 1026_ CGFDS 1031_ ECLNR 1036_ MLMFE 1041_ CHPQV 1046_ CPAGE 1051_ FCQNQ 1056_ CFTKR 1061_ QYPET 1066_ KIIKT 1071_ DGKGW 1076_ GLVAK 1081_ RDIRK 1086_ GEFVN 1091_ EYVGE 1096_ LIDEE 1101_ ECMAR 1106_ IKHAH 1111_ ENDIT 1116_ HFYML 1121_ TIDKD 1126_ RIIDA 1131_ GPKGN 1136_ YSRFM 1141_ NHSCQ 1146_ PNCET 1151_ LKWTV 1156_ NGDTR 1161_ VGLFA 1166_ VCDIP 1171_ AGTEL 1176_ TFNYN 1181_ LDCLG 1186_ NEKTV 1191_ CRCGA 1196_ SNCSG 1201_ FLGDR 1206_ PKTST 1211_ TLSSE 1216_ EKGKK 1221_ TKKKT 1226_ RRRRA 1231_ KGEGK 1236_ RQSED 1241_ ECFRC 1246_ GDGGQ 1251_ LVLCD 1256_ RKFCT 1261_ KAYHL 1266_ SCLGL 1271_ GKRPF 1276_ GKWEC 1281_ PWHHC 1286_ DVCGK 1291_ PSTSF 1296_ CHLCP 1301_ NSFCK 1306_ EHQDG 1311_ TAFSC 1316_ TPDGR 1321_ SYCCE 1326_ HDLGA 1331_ ASVRS 1336_ TKTEK 1341_ PPPEP 1346_ GKPKG 1351_ KRRRR 1356_RGWRR
1: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity)
2: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2)
3: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012)