All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)
1_MSTAG 6_ KVIKC 11_ KAAVL 16_ WEVKK 21_ PFSIE 26_ DVEVA 31_ PPKAY 36_ EVRIK 41_ MVAVG 46_ ICHTD 51_ DHVVS 56_ GNLVT 61_ PLPVI 66_ LGHEA 71_ AGIVE 76_ SVGEG 81_ VTTVK 86_ PGDKV 91_ IPLFT 96_ PQCGK 101_ CRVCK 106_ NPESN 111_ YCLKN 116_ DLGNP 121_ RGTLQ 126_ DGTRR 131_ FTCRG 136_ KPIHH 141_ FLGTS 146_ TFSQY 151_ TVVDE 156_ NAVAK 161_ IDAAS 166_ PLEKV 171_ CLIGC 176_ GFSTG 181_ YGSAV 186_ NVAKV 191_ TPGST 196_ CAVFG 201_ LGGVG 206_ LSAVM 211_ GCKAA 216_ GAARI 221_ IAVDI 226_ NKDKF 231_ AKAKE 236_ LGATE 241_ CINPQ 246_ DYKKP 251_ IQEVL 256_ KEMTD 261_ GGVDF 266_ SFEVI 271_ GRLDT 276_ MMASL 281_ LCCHE 286_ ACGTS 291_ VIVGV 296_ PPASQ 301_ NLSIN 306_ PMLLL 311_ TGRTW 316_ KGAVY 321_ GGFKS 326_ KEGIP 331_ KLVAD 336_ FMAKK 341_ FSLDA 346_ LITHV 351_ LPFEK 356_ INEGF 361_ DLLHS 366_GKSIR
1: Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820)