Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1)
1_MSSSG 6_ TPDLP 11_ VLLTD 16_ LKIQY 21_ TKIFI 26_ NNEWH 31_ DSVSG 36_ KKFPV 41_ FNPAT 46_ EEELC 51_ QVEEG 56_ DKEDV 61_ DKAVK 66_ AARQA 71_ FQIGS 76_ PWRTM 81_ DASER 86_ GRLLY 91_ KLADL 96_ IERDR 101_ LLLAT 106_ MESMN 111_ GGKLY 116_ SNAYL 121_ NDLAG 126_ CIKTL 131_ RYCAG 136_ WADKI 141_ QGRTI 146_ PIDGN 151_ FFTYT 156_ RHEPI 161_ GVCGQ 166_ IIPWN 171_ FPLVM 176_ LIWKI 181_ GPALS 186_ CGNTV 191_ VVKPA 196_ EQTPL 201_ TALHV 206_ ASLIK 211_ EAGFP 216_ PGVVN 221_ IVPGY 226_ GPTAG 231_ AAISS 236_ HMDID 241_ KVAFT 246_ GSTEV 251_ GKLIK 256_ EAAGK 261_ SNLKR 266_ VTLEL 271_ GGKSP 276_ CIVLA 281_ DADLD 286_ NAVEF 291_ AHHGV 296_ FYHQG 301_ QCCIA 306_ ASRIF 311_ VEESI 316_ YDEFV 321_ RRSVE 326_ RAKKY 331_ ILGNP 336_ LTPGV 341_ TQGPQ 346_ IDKEQ 351_ YDKIL 356_ DLIES 361_ GKKEG 366_ AKLEC 371_ GGGPW 376_ GNKGY 381_ FVQPT 386_ VFSNV 391_ TDEMR 396_ IAKEE 401_ IFGPV 406_ QQIMK 411_ FKSLD 416_ DVIKR 421_ ANNTF 426_ YGLSA 431_ GVFTK 436_ DIDKA 441_ ITISS 446_ ALQAG 451_ TVWVN 456_ CYGVV 461_ SAQCP 466_ FGGFK 471_ MSGNG 476_ RELGE 481_ YGFHE 486_ YTEVK 491_ TVTVK 496_ISQKN
1: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity)