Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)
1_MYRYL 6_ GEALL 11_ LSRAG 16_ PAALG 21_ SASAD 26_ SAALL 31_ GWARG 36_ QPAAA 41_ PQPGL 46_ ALAAR 51_ RHYSE 56_ AVADR 61_ EDDPN 66_ FFKMV 71_ EGFFD 76_ RGASI 81_ VEDKL 86_ VEDLR 91_ TRESE 96_ EQKRN 101_ RVRGI 106_ LRIIK 111_ PCNHV 116_ LSLSF 121_ PIRRD 126_ DGSWE 131_ VIEGY 136_ RAQHS 141_ QHRTP 146_ CKGGI 151_ RYSTD 156_ VSVDE 161_ VKALA 166_ SLMTY 171_ KCAVV 176_ DVPFG 181_ GAKAG 186_ VKINP 191_ KNYTD 196_ NELEK 201_ ITRRF 206_ TMELA 211_ KKGFI 216_ GPGID 221_ VPAPD 226_ MSTGE 231_ REMSW 236_ IADTY 241_ ASTIG 246_ HYDIN 251_ AHACV 256_ TGKPI 261_ SQGGI 266_ HGRIS 271_ ATGRG 276_ VFHGI 281_ ENFIN 286_ EASYM 291_ SILGM 296_ TPGFG 301_ DKTFV 306_ VQGFG 311_ NVGLH 316_ SMRYL 321_ HRFGA 326_ KCIAV 331_ GESDG 336_ SIWNP 341_ DGIDP 346_ KELED 351_ FKLQH 356_ GSILG 361_ FPKAK 366_ PYEGS 371_ ILEAD 376_ CDILI 381_ PAASE 386_ KQLTK 391_ SNAPR 396_ VKAKI 401_ IAEGA 406_ NGPTT 411_ PEADK 416_ IFLER 421_ NIMVI 426_ PDLYL 431_ NAGGV 436_ TVSYF 441_ EWLKN 446_ LNHVS 451_ YGRLT 456_ FKYER 461_ DSNYH 466_ LLMSV 471_ QESLE 476_ RKFGK 481_ HGGTI 486_ PIVPT 491_ AEFQD 496_ RISGA 501_ SEKDI 506_ VHSGL 511_ AYTME 516_ RSARQ 521_ IMRTA 526_ MKYNL 531_ GLDLR 536_ TAAYV 541_ NAIEK 546_ VFKVY 551_NEAGV
1: Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)