Gene name: DHFR

Uniprot entry:

P00374

Protein names:

Dihydrofolate reductase (EC 1.5.1.3)

Protein sequence:

1_MVGSL 6_ NCIVA 11_ VSQNM 16_ GIGKN 21_ GDLPW 26_ PPLRN 31_ EFRYF 36_ QRMTT 41_ TSSVE 46_ GKQNL 51_ VIMGK 56_ KTWFS 61_ IPEKN 66_ RPLKG 71_ RINLV 76_ LSREL 81_ KEPPQ 86_ GAHFL 91_ SRSLD 96_ DALKL 101_ TEQPE 106_ LANKV 111_ DMVWI 116_ VGGSS 121_ VYKEA 126_ MNHPG 131_ HLKLF 136_ VTRIM 141_ QDFES 146_ DTFFP 151_ EIDLE 156_ KYKLL 161_ PEYPG 166_ VLSDV 171_ QEEKG 176_ IKYKF 181_EVYEK

Protein annotations

Protein functions:

1: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2