Cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide I)
1_MFADR 6_ WLFST 11_ NHKDI 16_ GTLYL 21_ LFGAW 26_ AGVLG 31_ TALSL 36_ LIRAE 41_ LGQPG 46_ NLLGN 51_ DHIYN 56_ VIVTA 61_ HAFVM 66_ IFFMV 71_ MPIMI 76_ GGFGN 81_ WLVPL 86_ MIGAP 91_ DMAFP 96_ RMNNM 101_ SFWLL 106_ PPSLL 111_ LLLAS 116_ AMVEA 121_ GAGTG 126_ WTVYP 131_ PLAGN 136_ YSHPG 141_ ASVDL 146_ TIFSL 151_ HLAGV 156_ SSILG 161_ AINFI 166_ TTIIN 171_ MKPPA 176_ MTQYQ 181_ TPLFV 186_ WSVLI 191_ TAVLL 196_ LLSLP 201_ VLAAG 206_ ITMLL 211_ TDRNL 216_ NTTFF 221_ DPAGG 226_ GDPIL 231_ YQHLF 236_ WFFGH 241_ PEVYI 246_ LILPG 251_ FGMIS 256_ HIVTY 261_ YSGKK 266_ EPFGY 271_ MGMVW 276_ AMMSI 281_ GFLGF 286_ IVWAH 291_ HMFTV 296_ GMDVD 301_ TRAYF 306_ TSATM 311_ IIAIP 316_ TGVKV 321_ FSWLA 326_ TLHGS 331_ NMKWS 336_ AAVLW 341_ ALGFI 346_ FLFTV 351_ GGLTG 356_ IVLAN 361_ SSLDI 366_ VLHDT 371_ YYVVA 376_ HFHYV 381_ LSMGA 386_ VFAIM 391_ GGFIH 396_ WFPLF 401_ SGYTL 406_ DQTYA 411_ KIHFT 416_ IMFIG 421_ VNLTF 426_ FPQHF 431_ LGLSG 436_ MPRRY 441_ SDYPD 446_ AYTTW 451_ NILSS 456_ VGSFI 461_ SLTAV 466_ MLMIF 471_ MIWEA 476_ FASKR 481_ KVLMV 486_ EEPSM 491_ NLEWL 496_ YGCPP 501_ PYHTF 506_EEPVY
1: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix