Ceruloplasmin (EC 1.16.3.1) (Ferroxidase)
1_MKILI 6_ LGIFL 11_ FLCST 16_ PAWAK 21_ EKHYY 26_ IGIIE 31_ TTWDY 36_ ASDHG 41_ EKKLI 46_ SVDTE 51_ HSNIY 56_ LQNGP 61_ DRIGR 66_ LYKKA 71_ LYLQY 76_ TDETF 81_ RTTIE 86_ KPVWL 91_ GFLGP 96_ IIKAE 101_ TGDKV 106_ YVHLK 111_ NLASR 116_ PYTFH 121_ SHGIT 126_ YYKEH 131_ EGAIY 136_ PDNTT 141_ DFQRA 146_ DDKVY 151_ PGEQY 156_ TYMLL 161_ ATEEQ 166_ SPGEG 171_ DGNCV 176_ TRIYH 181_ SHIDA 186_ PKDIA 191_ SGLIG 196_ PLIIC 201_ KKDSL 206_ DKEKE 211_ KHIDR 216_ EFVVM 221_ FSVVD 226_ ENFSW 231_ YLEDN 236_ IKTYC 241_ SEPEK 246_ VDKDN 251_ EDFQE 256_ SNRMY 261_ SVNGY 266_ TFGSL 271_ PGLSM 276_ CAEDR 281_ VKWYL 286_ FGMGN 291_ EVDVH 296_ AAFFH 301_ GQALT 306_ NKNYR 311_ IDTIN 316_ LFPAT 321_ LFDAY 326_ MVAQN 331_ PGEWM 336_ LSCQN 341_ LNHLK 346_ AGLQA 351_ FFQVQ 356_ ECNKS 361_ SSKDN 366_ IRGKH 371_ VRHYY 376_ IAAEE 381_ IIWNY 386_ APSGI 391_ DIFTK 396_ ENLTA 401_ PGSDS 406_ AVFFE 411_ QGTTR 416_ IGGSY 421_ KKLVY 426_ REYTD 431_ ASFTN 436_ RKERG 441_ PEEEH 446_ LGILG 451_ PVIWA 456_ EVGDT 461_ IRVTF 466_ HNKGA 471_ YPLSI 476_ EPIGV 481_ RFNKN 486_ NEGTY 491_ YSPNY 496_ NPQSR 501_ SVPPS 506_ ASHVA 511_ PTETF 516_ TYEWT 521_ VPKEV 526_ GPTNA 531_ DPVCL 536_ AKMYY 541_ SAVDP 546_ TKDIF 551_ TGLIG 556_ PMKIC 561_ KKGSL 566_ HANGR 571_ QKDVD 576_ KEFYL 581_ FPTVF 586_ DENES 591_ LLLED 596_ NIRMF 601_ TTAPD 606_ QVDKE 611_ DEDFQ 616_ ESNKM 621_ HSMNG 626_ FMYGN 631_ QPGLT 636_ MCKGD 641_ SVVWY 646_ LFSAG 651_ NEADV 656_ HGIYF 661_ SGNTY 666_ LWRGE 671_ RRDTA 676_ NLFPQ 681_ TSLTL 686_ HMWPD 691_ TEGTF 696_ NVECL 701_ TTDHY 706_ TGGMK 711_ QKYTV 716_ NQCRR 721_ QSEDS 726_ TFYLG 731_ ERTYY 736_ IAAVE 741_ VEWDY 746_ SPQRE 751_ WEKEL 756_ HHLQE 761_ QNVSN 766_ AFLDK 771_ GEFYI 776_ GSKYK 781_ KVVYR 786_ QYTDS 791_ TFRVP 796_ VERKA 801_ EEEHL 806_ GILGP 811_ QLHAD 816_ VGDKV 821_ KIIFK 826_ NMATR 831_ PYSIH 836_ AHGVQ 841_ TESST 846_ VTPTL 851_ PGETL 856_ TYVWK 861_ IPERS 866_ GAGTE 871_ DSACI 876_ PWAYY 881_ STVDQ 886_ VKDLY 891_ SGLIG 896_ PLIVC 901_ RRPYL 906_ KVFNP 911_ RRKLE 916_ FALLF 921_ LVFDE 926_ NESWY 931_ LDDNI 936_ KTYSD 941_ HPEKV 946_ NKDDE 951_ EFIES 956_ NKMHA 961_ INGRM 966_ FGNLQ 971_ GLTMH 976_ VGDEV 981_ NWYLM 986_ GMGNE 991_ IDLHT 996_ VHFHG 1001_ HSFQY 1006_ KHRGV 1011_ YSSDV 1016_ FDIFP 1021_ GTYQT 1026_ LEMFP 1031_ RTPGI 1036_ WLLHC 1041_ HVTDH 1046_ IHAGM 1051_ ETTYT 1056_VLQNE
1: Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols (PubMed:10481051). Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis (PubMed:16906150)