Gene name: PNP

Uniprot entry:

P00491

Protein names:

Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)

Protein sequence:

1_MENGY 6_ TYEDY 11_ KNTAE 16_ WLLSH 21_ TKHRP 26_ QVAII 31_ CGSGL 36_ GGLTD 41_ KLTQA 46_ QIFDY 51_ GEIPN 56_ FPRST 61_ VPGHA 66_ GRLVF 71_ GFLNG 76_ RACVM 81_ MQGRF 86_ HMYEG 91_ YPLWK 96_ VTFPV 101_ RVFHL 106_ LGVDT 111_ LVVTN 116_ AAGGL 121_ NPKFE 126_ VGDIM 131_ LIRDH 136_ INLPG 141_ FSGQN 146_ PLRGP 151_ NDERF 156_ GDRFP 161_ AMSDA 166_ YDRTM 171_ RQRAL 176_ STWKQ 181_ MGEQR 186_ ELQEG 191_ TYVMV 196_ AGPSF 201_ ETVAE 206_ CRVLQ 211_ KLGAD 216_ AVGMS 221_ TVPEV 226_ IVARH 231_ CGLRV 236_ FGFSL 241_ ITNKV 246_ IMDYE 251_ SLEKA 256_ NHEEV 261_ LAAGK 266_ QAAQK 271_ LEQFV 276_ SILMA 281_SIPLP

Protein annotations

Protein functions:

1: Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964)